Alginates in metabolic syndrome

Kumar, Senthil Arun and Brown, Lindsay (2018) Alginates in metabolic syndrome. In: Alginates and their biomedical applications. Springer Series in Biomaterials Science and Engineering (11). Springer Nature, Singapore, pp. 223-235. ISBN 978-981-10-6909-3


Alginates extracted from seaweeds are widely used for nutrition, but they are underutilised for the prevention or reversal of human disease. Alginates are long chains of α-L-guluronic acid and β-D-mannuronic acid from brown seaweeds that act as readily available, low cost, non-toxic and biodegradable biopolymers. Sodium alginates are primarily used for the management of gastrointestinal tract disorders, but they are of potential use to attenuate the components of the metabolic syndrome including obesity, type 2 diabetes, hypertension, non-alcoholic fatty liver disease and dyslipidaemia. As prebiotics, alginates changed the gut microbiome to increase production of short-chain fatty acids as substrates for Bifidobacteria. Alginates inhibited pancreatic lipases and so decreased triacylglycerol breakdown and uptake. Treatment with alginates decreased food intake by inducing satiety and increased weight loss in patients on a calorie-restricted diet. Both glucose and fatty acid uptake were reduced. In rat models of hypertension, alginates decreased blood pressure. An alginate-antacid combination is an effective treatment of gastric reflux disease by forming a raft on the gastric contents. Alginates are important as drug carriers in microparticles and nanoparticles to increase drug bioavailability, for example, in drugs used for treatment of metabolic syndrome. Alginates are also used to protect cells during transplantation from immune responses of the host, allowing potential long-term control of some endocrine disorders such as type 1 diabetes and increased thermogenesis by brown adipocytes in obesity. There are many potential uses for these versatile biopolymers in the treatment of human disease.

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Item Type: Book Chapter (Commonwealth Reporting Category B)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021)
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021)
Date Deposited: 04 Jun 2018 02:59
Last Modified: 19 Sep 2018 03:52
Uncontrolled Keywords: alginates, metabolic syndrome, gastrointestinal tract, hypertension, inflammation, nanoparticle delivery, cell transplantation
Fields of Research (2008): 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
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