Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease

Ghattamaneni, Naga K. R. and Panchal, Sunil K. and Brown, Lindsay (2018) Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease. Pharmacological Research, 132. pp. 99-107. ISSN 1043-6618


Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation of all or part of the digestive tract. Nutraceuticals include bioactive compounds such as polyphenols with anti-inflammatory activities, thus these products have the potential to treat chronic inflammatory diseases. We have emphasized the role of nutraceuticals in ameliorating the symptoms of IBD in rodent models of human IBD through modulation of key pathogenic mechanisms including dysbiosis, oxidative stress, increased inflammatory cytokines, immune system dysregulation, and inflammatory cell signaling pathways. Nutraceuticals have an important role in IBD patients as a preventive approach to extend remission phases and as a therapeutic intervention to suppress active IBD. Further clinical trials on nutraceuticals with positive results in rodent models are warranted.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Restricted access to published version in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: Historic - Institute for Agriculture and the Environment
Date Deposited: 21 May 2018 06:37
Last Modified: 29 May 2018 00:59
Uncontrolled Keywords: Inflammatory Bowel Disease, inflammation, gut microbiota, polyphenols, cytokines
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.phrs.2018.04.015

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