Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats

Wanyonyi, Stephen and du Preez, Ryan and Brown, Lindsay and Paul, Nicholas A. and Panchal, Sunil K. (2017) Kappaphycus alvarezii as a food supplement prevents diet-induced metabolic syndrome in rats. Nutrients, 9 (11).

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Abstract

The red seaweed, Kappaphycus alvarezii, was evaluated for its potential to prevent signs of metabolic syndrome through use as a whole food supplement. Major biochemical components of dried Kappaphycus are carrageenan (soluble fiber ~34.6%) and salt (predominantly potassium (K) 20%) with a low overall energy content for whole seaweed. Eight to nine week old male Wistar rats were randomly divided into three groups and fed for 8 weeks on a corn starch diet, a high-carbohydrate, high-fat (H) diet, alone or supplemented with a 5% (w/w) dried and milled Kappaphycus blended into the base diet. H-fed rats showed symptoms of metabolic syndrome
including increased body weight, total fat mass, systolic blood pressure, left ventricular collagen deposition, plasma triglycerides, and plasma non-esterified fatty acids along with fatty liver. Relative to these obese rats, Kappaphycus-treated rats showed normalized body weight and adiposity, lower systolic blood pressure, improved heart and liver structure, and lower plasma lipids, even in presence of H diet. Kappaphycus modulated the balance between Firmicutes and Bacteroidetes in the gut, which could serve as the potential mechanism for improved metabolic variables; this was accompanied by no damage to the gut structure. Thus, whole Kappaphycus improved cardiovascular, liver, and metabolic parameters in obese rats.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty / Department / School: Current - Institute for Agriculture and the Environment
Date Deposited: 21 Dec 2017 00:09
Last Modified: 21 Dec 2017 00:09
Uncontrolled Keywords: metabolic syndrome; red seaweed; obesity; inflammation; carrageenan; Kappaphycus alvarezii
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.3390/nu9111261
URI: http://eprints.usq.edu.au/id/eprint/33500

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