affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebocontrolled clinical trial

Kell, Graham and Rao, Amanda and Beccaria, Gavin and Clayton, Paul and Inarejos-Garcia, Antonio Manuel and Prodanov, Marin (2017) affron® a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebocontrolled clinical trial. Complementary Therapies in Medicine, 33. pp. 58-64. ISSN 0965-2299

Abstract

Background

In recent years phytotherapy has been explored as a source for alternative treatments for mood disorders. One potential candidate is saffron (Crocus sativus L.), whose main bioactive components are crocins and safranal.
Objectives

The aim of this study was to investigate the efficacy of affron®, a standardised stigmas extract from Crocus sativus L. for improving mood, stress, anxiety and sleep quality in healthy adults.
Methods

In this 3 arm study, 128 participants self-reporting low mood but not diagnosed with depression, were given affron® at 28 mg/day, 22 mg/day, or a placebo treatment in a randomized, double-blind, placebo-controlled trial for 4 weeks. Mood was measured at baseline and at the end of the study, using the POMS (primary outcome measure) and PANAS questionnaires, and the DASS-21 scale. Sleep was monitored using Sleep Quality Index (PSQI).
Results

Analysis indicated a significant decrease in negative mood and symptoms related to stress and anxiety at a 28 mg/day dose (with a significant difference between 28 mg/day and placebo on the POMS Total Mood Disturbance scale, p < 0.001, d = −1.10), but no treatment effect at the 22 mg/day dose.
Limitations

The main weaknesses of this investigation were found in the self-reporting nature of both the screening and the testing.
Conclusions

affron® increased mood, reduced anxiety and managed stress without side effects, offering a natural alternative to standard treatments.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Psychology and Counselling
Date Deposited: 18 Dec 2017 07:05
Last Modified: 18 Dec 2017 07:05
Uncontrolled Keywords: Clinical trial; Mood disorders; Saffron extract; Phytonutrient; Depression
Fields of Research : 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110402 Naturopathy
Socio-Economic Objective: C Society > 92 Health > 9202 Health and Support Services > 920209 Mental Health Services
Identification Number or DOI: 10.1016/j.ctim.2017.06.001
URI: http://eprints.usq.edu.au/id/eprint/33072

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