Numerical human head modelling and investigation for precise tDCS applications

Song, Bo (2016) Numerical human head modelling and investigation for precise tDCS applications. [Thesis (PhD/Research)]

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Abstract

As a non-invasive and sub-convulsive functional stimulation technique, transcranial direct current stimulation (tDCS) generates a relatively weak current intensity and applies the moderate current to the brain to modulate the level of cortical excitability. This neuromodulatory technique has been extensively used as a potential clinical treatment for various neuropsychiatric conditions, ranging from depression, addition to schizophrenia and Parkinson’s disease. Recently, tDCS has also been researched as a promising alternative treatment to alleviate neuropathic pain of cancer patients.

The focus of this project is to numerically investigate the precise applications of tDCS based on a series of high resolution realistic human head model using finite element methods. Specifically, the influence of brain shift caused by gravity was firstly pre-validated using real shaped human head model. After that, this study focuses on the investigation of tDCS applications on the brain cancer patients in order to treat their neuropsychiatric conditions and neuropathic pain caused by the brain tumors. Thirdly, the role of blood vessels in shaping the induced current distributions within the cortex during tDCS was thoroughly investigated and addressed.

The outcomes of this project highlight the importance of head orientation during the clinical application of tDCS. The results also clear the safety concern in applying tDCS to the patients with brain cancer. In addition, this project provides positive supports on the introduction of brain blood vessels during the precise human head modelling for tDCS though considerable workload will be involved.


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Item Type: Thesis (PhD/Research)
Item Status: Live Archive
Additional Information: Doctor of Philosophy (PhD) thesis.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Agricultural, Computational and Environmental Sciences
Supervisors: Li, Yan
Date Deposited: 28 Jul 2017 03:09
Last Modified: 02 Aug 2017 03:32
Uncontrolled Keywords: transcranial direct current stimulation (tDCS); neuropsychiatric conditions
Fields of Research : 09 Engineering > 0906 Electrical and Electronic Engineering > 090699 Electrical and Electronic Engineering not elsewhere classified
URI: http://eprints.usq.edu.au/id/eprint/32871

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