The flavonoid rutin improves kidney and heart structure and function in an adenine-induced rat model of chronic kidney disease

Diwan, Vishal and Brown, Lindsay and Gobe, Glenda C (2017) The flavonoid rutin improves kidney and heart structure and function in an adenine-induced rat model of chronic kidney disease. Journal of Functional Foods, 33. pp. 85-93. ISSN 1756-4646

Abstract

Many foods contain rutin, a flavonoid with many health benefits. Here we tested rutin to reverse chronic kidney disease (CKD) and associated cardiovascular disease, using an established rodent model with adenine diet (0.25%) over 16 weeks. Rutin was added to the diet for the final 8 weeks. We measured kidney function (blood urea nitrogen/BUN, plasma creatinine/PCr, plasma uric acid, proteinuria); kidney structure (tubular damage, fibrosis, inflammation); cardiovascular function and structure (blood pressure, left ventricular stiffness, vascular responses, echocardiography, histology); and biomarkers for oxidative stress (HO-1), inflammation (PLA-2, TNF-α) and fibrosis (TGF-β). Adenine diet increased CKD characteristics (tubulointerstitial atrophy and fibrosis, inflammation, proteinuria, BUN, PCr, uric acid) and CKD-associated cardiovascular disease. Rutin improved kidney and heart structure and function, decreased HO-1 and PLA-2 expression, but did not reduce TGF-β or TNF-α. Decreased expression of HO-1 and PLA-2 appears to be a mechanistic pathway for reno- and cardioprotection.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 19 Nov 2017 22:50
Last Modified: 23 Apr 2018 03:39
Uncontrolled Keywords: chronic kidney disease; cardiovascular disease; inflammation; oxidative stress and rutin
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.jff.2017.03.012
URI: http://eprints.usq.edu.au/id/eprint/32704

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