Diwan, Vishal and Brown, Lindsay and Gobe, Glenda C (2017) The flavonoid rutin improves kidney and heart structure and function in an adenine-induced rat model of chronic kidney disease. Journal of Functional Foods, 33. pp. 85-93. ISSN 1756-4646
Abstract
Many foods contain rutin, a flavonoid with many health benefits. Here we tested rutin to reverse chronic kidney disease (CKD) and associated cardiovascular disease, using an established rodent model with adenine diet (0.25%) over 16 weeks. Rutin was added to the diet for the final 8 weeks. We measured kidney function (blood urea nitrogen/BUN, plasma creatinine/PCr, plasma uric acid, proteinuria); kidney structure (tubular damage, fibrosis, inflammation); cardiovascular function and structure (blood pressure, left ventricular stiffness, vascular responses, echocardiography, histology); and biomarkers for oxidative stress (HO-1), inflammation (PLA-2, TNF-α) and fibrosis (TGF-β). Adenine diet increased CKD characteristics (tubulointerstitial atrophy and fibrosis, inflammation, proteinuria, BUN, PCr, uric acid) and CKD-associated cardiovascular disease. Rutin improved kidney and heart structure and function, decreased HO-1 and PLA-2 expression, but did not reduce TGF-β or TNF-α. Decreased expression of HO-1 and PLA-2 appears to be a mechanistic pathway for reno- and cardioprotection.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | Files associated with this item cannot be displayed due to copyright restrictions. |
| Faculty/School / Institute/Centre: | Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021) |
| Faculty/School / Institute/Centre: | Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021) |
| Date Deposited: | 19 Nov 2017 22:50 |
| Last Modified: | 23 Apr 2018 03:39 |
| Uncontrolled Keywords: | chronic kidney disease; cardiovascular disease; inflammation; oxidative stress and rutin |
| Fields of Research (2008): | 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology |
| Fields of Research (2020): | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology |
| Socio-Economic Objectives (2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences |
| Identification Number or DOI: | https://doi.org/10.1016/j.jff.2017.03.012 |
| URI: | http://eprints.usq.edu.au/id/eprint/32704 |
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