Binocular rivalry and perceptual coherence 2 [Letter]

Ngo, Trung T. and Miller, Steven M. and Liu, Guang B. and Pettigrew, John D. (2000) Binocular rivalry and perceptual coherence 2 [Letter]. Current Biology, 10 (4). R134-R136. ISSN 0960-9822

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Background: At the core of the eukaryotic circadian network, clock genes/proteins form multiple transcriptional/translational negative-feedback loops and generate a basic 24 hr oscillation, which provides daily regulation for a wide range of processes. This temporal organization enhances the fitness of the organism only if it corresponds to the natural day/night cycles. Light is the most effective signal in synchronizing the oscillator to environmental cycles.
Results: The lip1-1 (light insensitive period 1) mutant isolated from the model plant Arabidopsis thaliana displays novel circadian phenotypes arising from specific defects in the light input pathway to the oscillator. In wild-type plants, period length shortens with increasing light fluence rates and the phase of rhythms can be shifted by light pulses administered to dark-adapted plants. In contrast, in lip1-1, period length is nearly insensitive to light intensity and significantly larger phase shifts (delays) can be induced during the subjective night. The mutant also displays elevated photomorphogenic responses to red and blue light, which cannot be explained by the circadian defect, suggesting distinct functions for LIP1 in the circadian light input and photomorphogenesis. The LIP1 gene encodes a functional, plant-specific atypical small GTPase, and therefore we postulate that it acts similarly to ZEITLUPE at postranscriptional level.

Conclusions: LIP1 represents the first small GTPase implicated in the circadian system of plants. LIP1 plays a unique negative role in controlling circadian light input and is required for precise entrainment of the plant clock.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: No
Item Status: Live Archive
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013)
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013)
Date Deposited: 22 Jul 2013 06:48
Last Modified: 28 Sep 2016 04:55
Uncontrolled Keywords: vision; neuroscience; visual cortex; perception
Fields of Research (2008): 11 Medical and Health Sciences > 1109 Neurosciences > 110906 Sensory Systems
01 Mathematical Sciences > 0102 Applied Mathematics > 010202 Biological Mathematics
11 Medical and Health Sciences > 1113 Ophthalmology and Optometry > 111303 Vision Science
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320907 Sensory systems
49 MATHEMATICAL SCIENCES > 4901 Applied mathematics > 490102 Biological mathematics
32 BIOMEDICAL AND CLINICAL SCIENCES > 3212 Ophthalmology and optometry > 321204 Vision science
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
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