Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health

Henson, J. and Yates, T. and Biddle, S. J. H. and Edwardson, C. L. and Khunti, K. and Wilmot, E. G. and Gray, L. J. and Gorely, T. and Nimmo, M. A. and Davies, M. J. (2013) Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health. Diabetologia, 56 (5). pp. 1012-1020. ISSN 0012-186X

Abstract

Aims/hypothesis: The study aimed to examine the associations between objectively measured sedentary time, breaks in sedentary time, moderate-to-vigorous physical activity (MVPA) and total physical activity with markers of cardiometabolic health in a population with known risk factors for type 2 diabetes mellitus. Methods: This study reports data from two ongoing diabetes prevention programmes. Participants with known risk factors were recruited from primary care practices located within the East Midlands, UK, over the period 2010-2011. ActiGraph GT3X accelerometers (15 s epochs) were used to assess sedentary time (<25 counts per 15 s), MVPA (≥488 counts per 15 s) and total physical activity (total counts). A break was considered as any interruption in sedentary time (≥25 counts per 15 s). Linear regression examined the independent association of sedentary time, breaks in sedentary time, MVPA and total physical activity with markers of cardiometabolic health. Results: The sample comprised 878 participants; 153 from Project STAND (Sedentary Time And Diabetes) (age 32.9 ± 5.6 years, 28.8% male) and 725 from Walking Away from Diabetes (age 63.7 ± 7.8 years, 64.8% male). Following adjustment for various covariates, including MVPA and BMI, there were detrimental linear associations of sedentary time with 2 h plasma glucose (standardised beta coefficient) (β = 0.220, p < 0.001), triacylglycerol (β = 0.206, p = 0.001) and HDL-cholesterol (β = -0.123, p = 0.029). Breaks in sedentary time, total physical activity and MVPA were significantly inversely associated with measures of adiposity, but not with any other cardiometabolic variables after adjustment for sedentary time and BMI. Conclusions/interpretation: In adults at high risk of type 2 diabetes mellitus, time spent sedentary is strongly and adversely associated with cardiometabolic health and may be a more important indicator of poor health than MVPA. © 2013 Springer-Verlag Berlin Heidelberg.


Statistics for USQ ePrint 31838
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 10 May 2017 02:04
Last Modified: 10 May 2017 02:04
Uncontrolled Keywords: Breaks in sedentary time; High risk; Physical activity; Primary care; Sedentary behaviour; Type 2 diabetes mellitus; General; Endocrinology; HORMONE-RELATED METABOLISM; Diabetes mellitus; Endocrinology; TREATMENT; Clinical and Experimental Biochemistry; METABOLISM; Clinical and Experimental Biochemistry; ANALYSIS; Clinical and Experimental Biochemistry; BLOOD CHEMISTRY; Biophysics, Bioengineering and Medical Instrumentation; Public Health, Social Medicine and Epidemiology; LIFE STYLES; Public Health, Social Medicine and Epidemiology; POPULATIONS AT RISK; Public Health, Social Medicine and Epidemiology; HEALTH CARE;
Fields of Research : 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
Socio-Economic Objective: C Society > 92 Health > 9299 Other Health > 929999 Health not elsewhere classified
Identification Number or DOI: 10.1007/s00125-013-2845-9
URI: http://eprints.usq.edu.au/id/eprint/31838

Actions (login required)

View Item Archive Repository Staff Only