Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research

Wilmot, E. G. and Edwardson, C. L. and Biddle, S. J. H. ORCID: and Gorely, T. and Henson, J. and Khunti, K. and Nimmo, M. A. and Yates, T. and Davies, M. J. (2013) Prevalence of diabetes and impaired glucose metabolism in younger 'at risk' UK adults: Insights from the STAND programme of research. Diabetic Medicine, 30 (6). pp. 671-675. ISSN 0742-3071


Aims: Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults. Methods: Overweight (with an additional risk factor) or obese adults (18-40 years) were recruited for the Sedentary Time And Diabetes (STAND) randomized controlled trial. Measures included an oral glucose tolerance test, HbA1c, biochemical and anthropometric data. Results: One hundred and ninety-three individuals (68% female; median age 33.8 years; median BMI 33.9 kg/m2) were recruited. Forty-three per cent had a first-degree family history of Type 2 diabetes. Previously undiagnosed Type 2 diabetes was present in 4.7% (n = 9). Of participants, 18.1% (n = 35) had impaired glucose metabolism: 4.7% (n = 9) HbA1c ≥ 48 mmol/mol (6.5%); 9.3% (n = 18) HbA1c 42-46 mmol/mol (6.0-6.4%); 3.1% (n = 6) Type 2 diabetes on oral glucose tolerance test; 6.2% (n = 12) isolated impaired glucose tolerance; 2.1% (n = 4) isolated impaired fasting glucose; 1% (n = 2) both impaired fasting glucose and impaired glucose tolerance. Of participants, 58.5% (n = 113) had dyslipidaemia, 28.0% (n = 54) had hypertension, 31.1% (n = 60) were vitamin D deficient and 7.3% (n = 14) had abnormal liver function. Conclusions: This study identified a high prevalence of Type 2 diabetes and impaired glucose regulation in overweight and obese younger adults. These findings require confirmation in a larger, representative, population. © 2013 Diabetes UK.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 11 May 2017 02:53
Last Modified: 11 May 2017 02:53
Uncontrolled Keywords: CLINICAL CHEMISTRY; PHYSIOLOGY; Endocrine Pancreas; Diabetes, insulin, and glucose tolerance; ENDOCRINOLOGY AND METABOLISM; CARBOHYDRATE METABOLISM; Glucose Transport and Metabolism; Public Health, Social Medicine and Epidemiology; HEALTH CARE; Public Health, Social Medicine and Epidemiology; EPIDEMIOLOGY, SCREENING AND PREVENTION; Public Health, Social Medicine and Epidemiology; POPULATIONS AT RISK; Endocrinology; HORMONE-RELATED METABOLISM; Diabetes mellitus; Internal Medicine; ENDOCRINE SYSTEM; Diabetes; Internal Medicine; EPIDEMIOLOGY AND PREVENTION;
Fields of Research (2008): 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
Fields of Research (2020): 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology
32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science
Socio-Economic Objectives (2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes
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