There is no association between the omega-3 index and depressive symptoms in patients with heart disease who are low fish consumers

Cai, Shaoxin and Coates, Alison M. and Buckley, Jonathan D. and Berry, Narelle M. and Burres, Lisa and Beltrame, John and Howe, Peter R. C. and Schrader, Geoffrey (2017) There is no association between the omega-3 index and depressive symptoms in patients with heart disease who are low fish consumers. Heart, Lung and Circulation, 26 (3). pp. 276-284. ISSN 1443-9506

Abstract

Background: Long chain Omega-3 polyunsaturated fatty acids (LCn3PUFAs) may improve cardiovascular health and depression. This study investigated the relationships between erythrocyte membrane LCn3PUFA status, depression and angina symptoms in patients with heart disease.

Methods: We recruited 91 patients (65 males and 26 females, mean age 59.2 ± 10.3 years) with heart disease and depressive symptoms (Center for Epidemiological Studies Depression Scale, CES-D ≥ 16) and low fish/fish oil intakes. The Omega-3 Index (EPA+DHA) of erythrocyte membranes (as a percentage of total fatty acids) was assessed by gas chromatography. Depression status was measured by both self-report and clinician-report scales; CES-D and the Hamilton depression scale (HAM-D). Angina symptoms were measured using the Seattle Angina Questionnaire and the Canadian Cardiovascular Society Classification for Angina Pectoris.

Results: The mean Omega-3 Index was 4.8 ± 1.0% (±SD). Depression scores measured by CES-D and HAM-D were 29.2 ± 8.8 (moderate to severe) and 11.0 ± 5.7 (mild) (arbitrary units) respectively reflecting a different perception of depressive symptoms between patients and clinicians. Angina status was inversely associated with depression scores (r > -0.26, P < 0.03). There were no significant relationships between individual LCn3PUFA or the Omega-3 Index and either the depression scores or the angina symptoms.

Conclusion: Worse angina status was associated with worse depression, but the Omega-3 Index was not associated with symptoms of depression or angina in patients with heart disease.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty / Department / School: No Faculty
Date Deposited: 15 Aug 2017 02:52
Last Modified: 02 Nov 2017 04:31
Uncontrolled Keywords: depression; heart disease; Omega-3 Index;
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
Identification Number or DOI: 10.1016/j.hlc.2016.07.003
URI: http://eprints.usq.edu.au/id/eprint/31621

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