Abdominal adiposity and obstructive airway disease: Testing insulin resistance and sleep disordered breathing mechanisms

Haren, Matthew T. and Misan, Gary and Paterson, Tracey Jayne and Ruffin, Richard E. and Grant, Janet F. and Buckley, Jonathan D. and Howe, Peter R. C. and Newbury, Jonathan and Taylor, Anne W. and McDermott, Robyn A. (2012) Abdominal adiposity and obstructive airway disease: Testing insulin resistance and sleep disordered breathing mechanisms. BMC Pulmonary Medicine, 12.

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Background: This study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB).Methods: A random sample of 2500 households was drawn from the community of Whyalla, South Australia (The Whyalla Intergenerational Study of Health, WISH February 2008 - July 2009). Seven-hundred twenty-two randomly selected adults (≥18 years) completed clinical protocols (32.2% response rate). Lung function was measured by spirometry. Post-bronchodilator FEV1/FVC was used to measure airway obstruction and reversibility of FEV1 was calculated. Current asthma was defined by self-reported doctor-diagnosis and evidence of currently active asthma. Symptom scores for asthma (CASS) and SDB were calculated. Intra-abdominal fat (IAF) was estimated using dual-energy x-ray absorptiometry (DXA). IR was calculated from fasting glucose and insulin concentrations.Results: The prevalence of current doctor-diagnosed asthma was 19.9% (95% CI 16.7 - 23.5%). The ratio of observed to expected cases given the age and sex distribution of the population was 2.4 (95%CI 2.1, 2.9). IAF was not associated with current doctor-diagnosed asthma, FEV1/FVC or FEV1 reversibility in men or women but was positively associated with CASS independent of IR and SDB in women. A 1% increase in IAF was associated with decreases of 12 mL and 20 mL in FEV1 and FVC respectively in men, and 4 mL and 7 mL respectively in women. SDB mediated 12% and 26% of these associations respectively in men but had minimal effects in women.Conclusions: In this population with an excess of doctor-diagnosed asthma, IAF was not a major factor in airway obstruction or doctor-diagnosed asthma, although women with higher IAF perceived more severe asthma symptoms which did not correlate with lower FEV1. Higher IAF was significantly associated with lower FEV1 and FVC and in men SDB mechanisms may contribute up to one quarter of this association.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version made available under Open Access.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 05 Jun 2017 00:33
Last Modified: 05 Jun 2017 00:33
Uncontrolled Keywords: Abdominal adiposity; Airway obstruction; Asthma; Forced Expiratory Volume; Forced Vital Capacity; Sleep disordered breathing; Chest Diseases, Thoracic Surgery and Tuberculosis; Endocrinology; Neurology and Neurosurgery;
Fields of Research (2008): 11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110203 Respiratory Diseases
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320103 Respiratory diseases
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: https://doi.org/10.1186/1471-2466-12-31
URI: http://eprints.usq.edu.au/id/eprint/31614

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