Milte, Catherine M. and Sinn, Natalie and Street, Steven J. and Buckley, Jonathan D. and Coates, Alison M. and Howe, Peter R. C. (2011) Erythrocyte polyunsaturated fatty acid status, memory, cognition and mood in older adults with mild cognitive impairment and healthy controls. Prostaglandins Leukotrienes and Essential Fatty Acids, 84 (5-6). pp. 153-161. ISSN 0952-3278
Abstract
Polyunsaturated fatty acid (PUFA) levels are altered in adults with cognitive decline and also depression. Depression facilitates progression from mild cognitive impairment (MCI) to dementia. We investigated associations between omega-3 (n-3) and omega-6 (n-6) PUFAs and cognition, memory and depression in 50 adults ≥65 years with MCI and 29 controls. Memory, depressive symptoms and erythrocyte PUFAs (% total fatty acids) were assessed. Eicosapentaenoic acid (EPA) was lower in MCI vs controls (.94% vs 1.26%, p<01); n-6 PUFAs were higher: dihomo-gamma-linolenic acid (1.51% vs 1.32%, p<01), arachidonic acid (11.54% vs 10.70%, p<01), n-6 docosapentaenoic acid (DPA:.46% vs.34%, p<01), and total n-6 PUFA (24.14% vs 23.37%, p<05). Higher n-6 DPA predicted poorer mental health. Lower n-3 DPA was associated with higher self-reported bodily pain. Adults with MCI had higher depression scores (3.05±39 vs 1.33±24, p<01). Depressive symptoms associated with elevated n-6 PUFA may contribute to cognitive decline in this population.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | Files associated with this item cannot be displayed due to copyright restrictions. |
| Faculty / Department / School: | No Faculty |
| Date Deposited: | 02 Jun 2017 06:16 |
| Last Modified: | 02 Jun 2017 06:16 |
| Uncontrolled Keywords: | Dementia; Depression; Mild cognitive impairment; Omega-3 fatty acids; Omega-6 fatty acids; Lipids, Glycolipids, and Polysaccharides; Memory and Learning |
| Fields of Research : | 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids |
| Socio-Economic Objective: | E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences |
| Identification Number or DOI: | 10.1016/j.plefa.2011.02.002 |
| URI: | http://eprints.usq.edu.au/id/eprint/31609 |
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