Transcranial doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture

McDonnell, Michelle N. and Berry, Narelle M. and Cutting, Mark A. and Keage, Hannah A. and Buckley, Jonathan D. and Howe, Peter R. C. (2013) Transcranial doppler ultrasound to assess cerebrovascular reactivity: reliability, reproducibility and effect of posture. PeerJ, 1 (Article e65). pp. 1-11.

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Abstract

Transcranial Doppler ultrasound (TCD) allows measurement of blood flow velocities in the intracranial vessels, and can be used to assess cerebral vasodilator responses to a hypercapnic stimulus. The reliability of this technique has not been established, nor is there agreement about whether the technique should be performed in sitting or lying postures.We tested the intra- and inter-rater reliability of measures of cerebrovascular reactivity (CVR) in 10 healthy adults, in sitting and lying postures. Participants underwent triplicate bilateral ultrasound assessment of flow velocities in the middle cerebral arteries whilst sitting and lying supine prior to and during inhalation of Carbogen (5% CO2, 95% O2) for 2 min. This procedure was performed twice by each of two raters for a total of four sessions. CVR was calculated as the difference between baseline and the peak blood flow velocity attained during CO2 inhalation. Intraclass correlation coefficients (ICCs) for intra-rater reliability were greater sitting than lying for both raters (e.g. Rater 1 ICC sitting D 0.822, lying D 0.734), and inter-rater reliability was also greater in sitting (e.g. sitting ICC D 0.504, lying D 0.081). These results suggest that assessment of CVR using TCD should be performed with participants sitting in order to maximise CVR measurement reliability. © 2013 McDonnell et al.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version made available under Open Access.
Faculty / Department / School: No Faculty
Date Deposited: 05 Jun 2017 23:38
Last Modified: 08 Feb 2018 03:47
Uncontrolled Keywords: Cerebrovascular reactivity; Doppler ultrasound; Posture; Reliability; Reproducibility; Cardiovascular Diseases and Cardiovascular Surgery
Fields of Research : 11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.7717/peerj.65
URI: http://eprints.usq.edu.au/id/eprint/31592

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