Evidence for circulatory benefits of Resveratrol in humans

Wong, Rachel H. X. and Coates, Alison M. and Buckley, Jonathan D. and Howe, Peter R. C. (2013) Evidence for circulatory benefits of Resveratrol in humans. Annals of the New York Academy of Sciences, 1290 (1). pp. 52-58. ISSN 0077-8923

Abstract

Impairments of endothelial function, which can be assessed noninvasively by flow-mediated dilation (FMD) of the brachial artery, contribute to the development of cardiovascular disease. Associations between FMD and cognition suggest a vascular component in the loss of cognitive function. Certain vasoactive nutrients that have been shown to improve FMD may also have the potential to enhance cerebral perfusion and cognition. Preclinical studies show that trans-resveratrol can enhance nitric oxide bioavailability, thereby increasing endothelium-dependent vasodilation. We have now shown that acute administration of resveratrol elicits dose-dependent increases of FMD with greater potency than other vasoactive nutrients and that this benefit is sustained following regular consumption. We describe the potential implications of this vasodilator benefit of resveratrol and its role in enhancing cerebrovascular and cognitive functions.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 05 Jun 2017 04:40
Last Modified: 05 Jun 2017 07:02
Uncontrolled Keywords: Endothelial function; Flow-mediated dilation; Human; Resveratrol; trans-resveratrol; Vasodilator responsiveness; Cardiovascular Diseases and Cardiovascular Surgery; Clinical and Experimental Pharmacology
Fields of Research : 11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110299 Cardiovascular Medicine and Haematology not elsewhere classified
Socio-Economic Objective: C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1111/nyas.12155
URI: http://eprints.usq.edu.au/id/eprint/31590

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