Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with adhd in a randomized controlled three-way crossover trial

Milte, Catherine M. and Parletta, Natalie and Buckley, Jonathan D. and Coates, Alison M. and Young, Ross M. and Howe, Peter R. C. (2015) Increased erythrocyte eicosapentaenoic acid and docosahexaenoic acid are associated with improved attention and behavior in children with adhd in a randomized controlled three-way crossover trial. Journal of Attention Disorders, 19 (11). pp. 954-964. ISSN 1087-0547

Abstract

Objective: To investigate effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on attention, literacy, and behavior in children with ADHD. Method: Ninety children were randomized to consume supplements high in EPA, DHA, or linoleic acid (control) for 4 months each in a crossover design. Erythrocyte fatty acids, attention, cognition, literacy, and Conners’ Parent Rating Scales (CPRS) were measured at 0, 4, 8, 12 months. Results: Fifty-three children completed the treatment. Outcome measures showed no significant differences between the three treatments. However, in children with blood samples (n = 76-46), increased erythrocyte EPA + DHA was associated with improved spelling (r =.365, p <.001) and attention (r = −.540, p <.001) and reduced oppositional behavior (r = −.301, p <.003), hyperactivity (r = −.310, p <.001), cognitive problems (r = −.326, p <.001), Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) hyperactivity (r = −.270, p =.002) and DSM-IV inattention (r = −.343, p <.001). Conclusion: Increasing erythrocyte DHA and EPA via dietary supplementation may improve behavior, attention, and literacy in children with ADHD.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 04 Jun 2017 23:41
Last Modified: 04 Jun 2017 23:41
Uncontrolled Keywords: ADD/ADHD; Behavior; Cognition; Fatty acid; Nutrition; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior; Cognition; Dietary Fats; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Erythrocytes; Fatty Acids, Omega-3
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1177/1087054713510562
URI: http://eprints.usq.edu.au/id/eprint/31575

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