Potential implications of dose and diet for the effects of eocoa flavanols on cardiometabolic function

Davison, Kade and Howe, Peter R C (2015) Potential implications of dose and diet for the effects of eocoa flavanols on cardiometabolic function. Journal of Agricultural and Food Chemistry, 63 (45). pp. 9942-9947. ISSN 0021-8561

Abstract

The metabolic syndrome is a pathological state whereby cardiovascular and metabolic dysfunction coexist and typically progress in a mutual feed-forward manner to further dysfunction and ultimately disease. The health and function of the vascular endothelium is integral in this phenomenon and thus represents a logical target for intervention. Consumption of foods high in cocoa flavanols has demonstrated a capacity to markedly improve endothelial function and key markers of the metabolic syndrome including blood pressure and insulin sensitivity. The typically high energy content of foods containing sufficient doses of cocoa flavanols has caused some reservations around its therapeutic use, but this is dependent upon the particulars of the food matrix used. Further to this, the food matrix appears to influence the dose response curve of cocoa flavanols, particularly on blood pressure, with dark chocolate appearing to be 8 times more effective in systolic blood pressure reduction than a cocoa powder drink for the equivalent dose of flavanol. Cocoa flavanol consumption conclusively demonstrates a positive impact on cardiometabolic function; however, more research is needed to understand how best to consume it to maximize the benefit while avoiding excessive fat and sugar consumption.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 04 Jun 2017 23:43
Last Modified: 04 Jun 2017 23:43
Uncontrolled Keywords: blood pressure; cocoa; dark chocolate; dose response; metabolic syndrome; vascular endothelium; Dark chocolate; Dose response; Dose-response curves; Endothelial function; Insulin sensitivity; Metabolic syndromes; Systolic blood pressure; Vascular endothelium; Animals; Blood Pressure; Cacao; Cardiovascular Diseases
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1021/acs.jafc.5b01492
URI: http://eprints.usq.edu.au/id/eprint/31573

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