Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review

Fulton, Ashley S. and Hill, Alison M. and Williams, Marie T. and Howe, Peter R. C. and Coates, Alison M. (2015) Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review. Nutrition Reviews, 73 (9). pp. 612-623. ISSN 0029-6643

Abstract

Context: The anti-inflammatory activity of long-chain n-3 polyunsaturated fatty acids (PUFAs) has been established in several chronic inflammatory diseases but has yet to be demonstrated in inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD). Objective: The aim of this systematic review was to investigate, using PRISMA guidelines, the relationship between the intake of long-chain n-3 PUFAs and the prevalence, severity, and health outcomes of COPD. Data Sources: Eight health databases and the World Health Organization's international clinical trial registry were searched for relevant studies. Study Selection: Experimental or observational studies that were published in English and that assessed long-chain n-3 PUFA intake (by determining habitual consumption and/or tissue levels) in adults with COPD were included. Data Extraction: Publication demographics, participant characteristics, type of intervention or exposure, long-chain n-3 PUFA intake, pulmonary function, COPD mortality, and COPD severity were independently extracted from each article by 2 authors using a prospectively designed data extraction tool. Data Synthesis: All 11 of the studies included in the review were observational. Approximately equal numbers of studies reported significant (n=6, 5 inverse) relationships or no significant relationships (n=5) between either consumption of long-chain n-3 PUFAs or levels of long-chain n-3 PUFAS in tissue and a COPD outcome. Conclusions: Current evidence of a relationship between long-chain n-3 PUFA intake and COPD is limited and conflicting, with studies having wide methodological variation. Registration number: PROSPERO 2013:CRD42013004085.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: No Faculty
Date Deposited: 04 Jun 2017 23:42
Last Modified: 04 Jun 2017 23:42
Uncontrolled Keywords: Chronic obstructive pulmonary disease; COPD; LCn-3 PUFA; long-chain n-3 fatty acid; Polyunsaturated fatty acid; Systematic review; Chronic Disease; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Prevalence; Pulmonary Disease, Chronic Obstructive; Nutrition and Immunity; Chronic Inflammation, Delayed Hypersensitivity, Contact Sensitivity; Human studies; Chest Diseases, Thoracic Surgery and Tuberculosis
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111199 Nutrition and Dietetics not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1093/nutrit/nuv017
URI: http://eprints.usq.edu.au/id/eprint/31570

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