Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment

Street, Steven John and Parletta, Natalie and Milte, Catherine and Sullivan, Karen and Hills, Andrew P. and Buckley, Jonathan and Howe, Peter (2015) Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment. Aging and Mental Health, 19 (10). pp. 885-891. ISSN 1360-7863


Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3 polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive impairment (MCI) in older adults.Method: A cross-sectional study was conducted. Community-dwelling male and female (n = 84) participants over the age of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire.Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with increased odds of a non-MCI classification.Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults.

Statistics for USQ ePrint 31568
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 02 Jun 2017 06:06
Last Modified: 02 Jun 2017 06:06
Uncontrolled Keywords: ageing; DHA; EPA; mild cognitive impairment; physical activity; Aged; Aged, 80 and over; Aging; Cross-Sectional Studies; Dietary Supplements; Docosahexaenoic Acids; Eicosapentaenoic Acid; Erythrocytes; Fatty Acids, Omega-3; Female; Mild Cognitive Impairment; Motor Activity; Surveys and Questionnaires
Fields of Research (2008): 11 Medical and Health Sciences > 1117 Public Health and Health Services > 111702 Aged Health Care
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI:

Actions (login required)

View Item Archive Repository Staff Only