Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes

Nealon, Rhenan Scott and Howe, Peter Ranald Charles and Jansen, Lyanne and Garg, Manohar and Wong, Rachel Heloise Xiwen (2017) Impaired cerebrovascular responsiveness and cognitive performance in adults with type 2 diabetes. Journal of Diabetes and its Complications, 31 (2). pp. 462-467. ISSN 1056-8727


Aim: Cognitive deficits in type 2 diabetes mellitus (T2DM) may be partly attributable to stiffness in cerebral arteries and impaired vasodilator function, limiting the ability to increase blood flow in brain regions to meet cognitive demands. We undertook a comparison of cerebrovascular responsiveness (CVR) and cognitive performance in adults with and without T2DM.

Methods: Older adults with (50) and without (Herath, Cherbuin, Eramudugolla, & Anstey, 2016) T2DM underwent transcranial Doppler ultrasound measurements of basal cerebral mean blood flow velocity (MBFV) and pulsatility index (PI), a measure of arterial stiffness, in the middle cerebral arteries (MCA). A battery of tasks assessing domains of working memory, executive function and information processing/motor speed was then administered while MBFV was recorded. CVR to cognitive tasks was calculated as a percentage increase in MBFV from the basal level.

Results: There was no difference in basal MBFV between groups. However, PI was 14% higher in the T2DM group (P < 0.05), who performed poorer across all cognitive domains assessed and displayed poorer CVR in three tasks. Cognitive performance was inversely related to the PI/MBFV ratio, an indicator of intracranial stenosis.

Discussion: Impaired cerebral perfusion during mental tasks is accompanied by poor cognitive performance and stiffness in the cerebral vessels.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 15 Aug 2017 02:15
Last Modified: 18 Apr 2018 03:47
Uncontrolled Keywords: arterial stiffness; cerebral perfusion; cognitive decline; diabetes mellitus; transcranial doppler
Fields of Research (2008): 11 Medical and Health Sciences > 1116 Medical Physiology > 111699 Medical Physiology not elsewhere classified
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3208 Medical physiology > 320899 Medical physiology not elsewhere classified
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