Mills, Dean and Johnson, Michael and McPhilimey, Martin and Williams, Neil and Gonzalez, Javier and Barnett, Yvonne and Sharpe, Graham (2012) The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea. In: 22nd European Respiratory Society Annual Congress, 1-5 Sept 2012, Vienna, Austria.
Abstract
Vassilakopoulos et al. (Am. J. Physiol 1999; 277:R1013–R1019) demonstrated a breathing-induced interleukin-6 (IL-6) response. Whether inspiratory muscle training (IMT) can attenuate this response is unknown. Therefore, we tested the hypothesis that the IL-6 response to volitional hyperpnoea (VH) could be reduced with IMT and investigated whether this response was related to diaphragm fatigue (assessed by phrenic nerve stimulation) and/or changes in blood lactate concentration ([Lac-]B).
Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Prior to training, a maximal incremental cycling test (max) was performed. Before and after training, participants undertook two 1 h experimental trials on separate days: passive rest or VH. In VH, they voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern equal to 70-80% of the maximum minute ventilation achieved during max.
IL-6 increased (P<0.01) following the pre-training VH and was (mean ± SD) 5.02 ± 0.63 and 4.87 ± 0.86 pg·mL-1 at 2 h post for IMT and PLA groups, respectively. [Lac-]B remained (P<0.01) elevated above baseline values for the duration of VH at 1.36 ± 0.24 and 1.29 ± 0.18 mmol⋅L-1. The IL-6 (-29%) and [Lac-]B (-11%) responses were reduced (P<0.05) for the IMT, but not for the PLA group. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest and no evidence of diaphragm fatigue during any trial.
In conclusion, 6 weeks of IMT reduces the magnitude of the IL-6 response to VH with no evidence of diaphragm fatigue. The reduction in IL-6 may be related to the post-IMT reduction in [Lac-]B.
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| Item Type: | Conference or Workshop Item (Commonwealth Reporting Category E) (Poster) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | Poster presentation. Abstract only published. http://www.ers-education.org/ersMade/abstract_print_12/main_frameset.htm |
| Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Nursing (Up to 30 Jun 2013) |
| Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Nursing (Up to 30 Jun 2013) |
| Date Deposited: | 22 Mar 2017 05:43 |
| Last Modified: | 30 Jun 2017 05:22 |
| Uncontrolled Keywords: | immunology; anti-inflammatory; respiratory muscle |
| Fields of Research (2008): | 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology |
| Fields of Research (2020): | 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology |
| URI: | http://eprints.usq.edu.au/id/eprint/30953 |
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