The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea

Mills, Dean and Johnson, Michael and McPhilimey, Martin and Williams, Neil and Gonzalez, Javier and Barnett, Yvonne and Sharpe, Graham (2012) The effects of inspiratory muscle training on the interleukin-6 response to intense volitional hyperpnoea. In: 22nd European Respiratory Society Annual Congress, 1-5 Sept 2012, Vienna, Austria.

Abstract

Vassilakopoulos et al. (Am. J. Physiol 1999; 277:R1013–R1019) demonstrated a breathing-induced interleukin-6 (IL-6) response. Whether inspiratory muscle training (IMT) can attenuate this response is unknown. Therefore, we tested the hypothesis that the IL-6 response to volitional hyperpnoea (VH) could be reduced with IMT and investigated whether this response was related to diaphragm fatigue (assessed by phrenic nerve stimulation) and/or changes in blood lactate concentration ([Lac-]B).

Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Prior to training, a maximal incremental cycling test (max) was performed. Before and after training, participants undertook two 1 h experimental trials on separate days: passive rest or VH. In VH, they voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern equal to 70-80% of the maximum minute ventilation achieved during max.

IL-6 increased (P<0.01) following the pre-training VH and was (mean ± SD) 5.02 ± 0.63 and 4.87 ± 0.86 pg·mL-1 at 2 h post for IMT and PLA groups, respectively. [Lac-]B remained (P<0.01) elevated above baseline values for the duration of VH at 1.36 ± 0.24 and 1.29 ± 0.18 mmol⋅L-1. The IL-6 (-29%) and [Lac-]B (-11%) responses were reduced (P<0.05) for the IMT, but not for the PLA group. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest and no evidence of diaphragm fatigue during any trial.

In conclusion, 6 weeks of IMT reduces the magnitude of the IL-6 response to VH with no evidence of diaphragm fatigue. The reduction in IL-6 may be related to the post-IMT reduction in [Lac-]B.


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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: Yes
Item Status: Live Archive
Additional Information: Poster presentation. Abstract only published. http://www.ers-education.org/ersMade/abstract_print_12/main_frameset.htm
Faculty / Department / School: Historic - Faculty of Sciences - Department of Nursing
Date Deposited: 22 Mar 2017 05:43
Last Modified: 30 Jun 2017 05:22
Uncontrolled Keywords: immunology; anti-inflammatory; respiratory muscle
Fields of Research : 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
URI: http://eprints.usq.edu.au/id/eprint/30953

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