The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea

Mills, Dean and Johnson, Michael and McPhilimey, Martin and Williams, Neil and Gonzalez, Javier and Barnett, Yvonne and Sharpe, Graham (2012) The effects of inspiratory muscle training on interleukin-6 concentration during cycling exercise and volitional hyperpnoea. In: 22nd European Respiratory Society Annual Congress, 1-5 Sept 2012, Vienna, Austria.

Abstract

The plasma concentration of interleukin-6 (IL-6) increases during cycling exercise (EX) (Starkie et al. J. Physiol 2001; 533:585-591) and inspiratory resistive breathing (IRB) (Vassilakopoulos et al. Am. J. Physiol 1999; 277:R1013–R1019). Whether inspiratory muscle training (IMT) can attenuate the magnitude of the IL-6 response to EX and volitional hyperpnoea (VH) rather than IRB is unknown. Therefore, we tested the hypothesis that IMT would reduce the IL-6 response to EX and/or VH.

Twelve male participants performed either 6 weeks of pressure-threshold IMT (n=6) or placebo (PLA) training (n=6). Before and after training, participants undertook three 1 hour experimental trials on separate days: (i) passive rest; (ii) EX; and (iii) VH. EX was performed at maximum lactate steady state power. In VH, participants voluntarily mimicked at rest the breathing and respiratory muscle recruitment pattern attained during EX.

IL-6 peaked immediately after EX for both the IMT and PLA groups (6.75 ± 1.6 and 5.64 ± 1.76 pg·mL-1). Following training, this response was reduced (-33%; P=0.027) for the IMT but not the PLA group. Blood lactate concentration ([Lac-]B) during EX was also reduced (-35%; P=0.009) for the IMT group only. IL-6 and [Lac-]B increased (P<0.05) during VH in both groups, but there was no effect of training on these responses. There were no increases in IL-6 or [Lac-]B over time for either group during passive rest.

In conclusion, 6 weeks of IMT reduces IL-6 during EX but not VH. The reduction in IL-6 concentration following IMT may be related to a decreased carbohydrate utilisation as indicated by the post-IMT reduction in [Lac-]B during EX but not VH.


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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: Yes
Item Status: Live Archive
Additional Information: Poster presentation. Abstract only published. http://www.ers-education.org/ersMade/abstract_print_12/main_frameset.htm
Faculty / Department / School: Historic - Faculty of Sciences - Department of Nursing
Date Deposited: 22 Mar 2017 04:53
Last Modified: 30 Jun 2017 05:20
Uncontrolled Keywords: immunology; anti-inflammatory; exercise
Fields of Research : 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
URI: http://eprints.usq.edu.au/id/eprint/30952

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