Analysis of strain-rate dependent mechanical behavior of single chondrocyte: a finite element study

Gu, YuanTong and Nguyen, Trung Dung and Oloyede, Adekunle and Senadeera, Wijitha (2014) Analysis of strain-rate dependent mechanical behavior of single chondrocyte: a finite element study. International Journal of Computational Methods, 11 (Suppl 1). pp. 1344005-1. ISSN 0219-8762


Various studies have been conducted to investigate the effects of impact loading on cartilage damage and chondrocyte death. These have shown that the rate and magnitude of the applied strain significantly influence chondrocyte death, and that cell death occurred mostly in the superficial zone of cartilage suggesting the need to further understand the fundamental mechanisms underlying the chondrocytes death induced at certain levels of strain-rate. To date there is no comprehensive study providing insight on this phenomenon. The aim of this study is to examine the strain-rate dependent behavior of a single chondrocyte using a computational approach based on finite element method (FEM). An FEM model was developed using various mechanical models, which were standard Neo-Hookean solid (SnHS), porohyperelastic (PHE) and poroviscohyperelastic(PVHE) to simulate atomic force microscopy (AFM) experiments of chondrocyte. The PVHE showed, it can capture both relaxation and loading rate dependent behaviors of chondrocytes, accurately compared to other models.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: Current - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering
Date Deposited: 09 Feb 2017 05:13
Last Modified: 20 Nov 2017 06:54
Uncontrolled Keywords: porohyperelastic; chondrocyte; finite element method (FEM); biomechanics
Fields of Research : 09 Engineering > 0903 Biomedical Engineering > 090302 Biomechanical Engineering
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970109 Expanding Knowledge in Engineering
Identification Number or DOI: 10.1142/S0219876213440052

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