Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats

Kumar, Senthil A. and Ward, Leigh C. and Brown, Lindsay (2016) Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats. British Journal of Nutrition, 116 (9). pp. 1502-1511. ISSN 0007-1145

Abstract

Prebiotics alter bacterial content in the colon, and therefore could be useful for obesity management. We investigated the changes following addition of inulin oligofructose (IO) in the food of rats fed either a corn starch (C) diet or a high-carbohydrate, high-fat (H) diet as a model of diet-induced metabolic syndrome. IO did not affect food intake, but reduced body weight gain by 5·3 and 12·3% in corn starch + inulin oligofructose (CIO) and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively. IO reduced plasma concentrations of free fatty acids by 26·2% and TAG by 75·8% in HIO rats. IO increased faecal output by 93·2%, faecal lipid excretion by 37·9% and weight of caecum by 23·4% and colon by 41·5% in HIO rats. IO improved ileal morphology by reducing inflammation and improving the density of crypt cells in HIO rats. IO attenuated H diet-induced increases in abdominal fat pads (C 275 (SEM 19), CIO 264 (SEM 40), H 688 (SEM 55), HIO 419 (SEM 32)mg/mm tibial length), fasting blood glucose concentrations (C 4·5 (SEM 0·1), CIO 4·2 (SEM 0·1), H 5·2 (SEM 0·1), HIO 4·3 (SEM 0·1) mmol/l), systolic blood pressure (C 124 (SEM 2), CIO 118 (SEM 2), H 152 (SEM 2), HIO 123 (SEM 3) mmHg), left ventricular diastolic stiffness (C 22·9 (SEM 0·6), CIO 22·9 (SEM 0·5), H 27·8 (SEM 0·5), HIO 22·6 (SEM 1·2)) and plasma alanine transaminase (C 29·6 (SEM 2·8), CIO 32·1 (SEM 3·0), H 43·9 (SEM 2·6), HIO 33·6 (SEM 2·0) U/l). IO attenuated H-induced increases in inflammatory cell infiltration in the heart and liver, lipid droplets in the liver and plasma lipids as well as impaired glucose and insulin tolerance. These results suggest that increasing soluble fibre intake with IO improves signs of the metabolic syndrome by decreasing gastrointestinal carbohydrate and lipid uptake.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Second place winner for the USQ School-Specific 2016 Publication Excellence Awards for Journal Articles - School of Health and Wellbeing. Published version not accessible until December 2017.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 02 Mar 2017 01:26
Last Modified: 24 Jan 2018 02:36
Uncontrolled Keywords: inulin; oligofructose; prebiotics; metabolic syndrome; rats
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1017/s0007114516003627
URI: http://eprints.usq.edu.au/id/eprint/30481

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