Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: pharmacological and metabolism-based investigation

Poudyal, Hemant and Lemonakis, Nikolaos and Efentakis, Panagiotis and Gikas, Evangelos and Halabalaki, Maria and Andreadou, Ioanna and Skaltsounis, Leandros and Brown, Lindsay (2017) Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: pharmacological and metabolism-based investigation. Pharmacological Research, 117. pp. 32-45. ISSN 1043-6618

Abstract

Metabolic syndrome is a clustering of interrelated risk factors for cardiovascular disease and diabetes.The Mediterranean diet has been proposed as an important dietary pattern to confer cardioprotectionby attenuating risk factors of metabolic syndrome. Hydroxytyrosol (HT) is present in olive fruit and oil,which are basic constituents of the Mediterranean diet. In this study, we have shown that treatmentwith HT (20 mg/kg/d for 8 weeks) decreased adiposity, improved impaired glucose and insulin tolerance,improved endothelial function with lower systolic blood pressure, decreased left ventricular fibrosis andresultant diastolic stiffness and reduced markers of liver damage in a diet-induced rat model of metabolicsyndrome. These results were accompanied by reduced infiltration of monocytes/macrophages into theheart with reduced biomarkers of oxidative stress. Furthermore, in an HRMS-based metabolism study ofHT, we have identified 24 HT phase I and II metabolites, six of them being over-produced in high-starch,low-fat diet fed rats treated with HT compared to obese rats on high-carbohydrate, high-fat diet. Theseresults provide direct evidence for cardioprotective effects of hydroxytyrosol by attenuation of metabolicrisk factors. The implications of altered metabolism of HT in high-carbohydrate, high-fat diet fed obeserats warrant further investigation.


Statistics for USQ ePrint 30479
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 16 Oct 2017 00:39
Last Modified: 16 Apr 2018 23:06
Uncontrolled Keywords: hydroxytyrosol, olives, olive oil, metabolic syndrome, cardiovascular, obesity
Fields of Research : 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.phrs.2016.12.002
URI: http://eprints.usq.edu.au/id/eprint/30479

Actions (login required)

View Item Archive Repository Staff Only