Changes in non-diabetic comorbid disease status following Laparoscopic Vertical Sleeve Gastrectomy (LVSG) versus Laparoscopic Roux-En-Y Gastric Bypass (LRYGB) procedures: a systematic review of randomized controlled trials

Osland, Emma and Yunus, Rossita Mohamad and Khan, Shahjahan and Memon, Muhammed Ashraf and Memon, Breda (2017) Changes in non-diabetic comorbid disease status following Laparoscopic Vertical Sleeve Gastrectomy (LVSG) versus Laparoscopic Roux-En-Y Gastric Bypass (LRYGB) procedures: a systematic review of randomized controlled trials. Obesity Surgery, 27 (5). pp. 1208-12221. ISSN 0960-8923

Abstract

PURPOSE:
Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic vertical sleeve gastrectomy (LVSG) have been proposed as cost-effective strategies to manage obesity-related chronic disease. The aim of this systematic review was to study the peer review literature regarding postoperative nondiabetic comorbid disease resolution or improvement reported from randomized controlled trials (RCTs) comparing LVSG and LRYGB procedures.
MATERIAL AND METHODS:
RCTs comparing postoperative comorbid disease resolution such as hypertension, dyslipidemia, obstructive sleep apnea, joint and musculoskeletal conditions, gastroesophageal reflux disease, and menstrual irregularities following LVSG and LRYGB were included for analysis. The studies were selected from PubMed, Medline, EMBASE, Science Citation Index, Current Contents, and the Cochrane database and reported on at least one comorbidity resolution or improvement. The present work was undertaken according to the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA). The Jadad method for assessment of methodological quality was applied to the included studies.
RESULTS:
Six RCTs performed between 2005 and 2015 involving a total of 695 patients (LVSG n = 347, LRYGB n = 348) reported on the resolution or improvement of comorbid disease following LVSG and LRYGB procedures. Both bariatric procedures provide effective and almost comparable results in improving or resolving these comorbidities.
CONCLUSIONS:
This systematic review of RCTs suggests that both LVSG and LRYGB are effective in resolving or improving preoperative nondiabetic comorbid diseases in obese patients. While results are not conclusive at this time, LRYGB may provide superior results compared to LVSG in mediating the remission and/or improvement in some conditions such as dyslipidemia and arthritis.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version, in accordance with the copyright policy of the publisher.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Agricultural, Computational and Environmental Sciences
Date Deposited: 09 Mar 2017 01:03
Last Modified: 19 Dec 2017 23:15
Uncontrolled Keywords: bariatric surgery; obesity; laparoscopic; sleeve gastrectomy; roux-en-Y gastric bypass; meta-analysis; systematic review
Fields of Research : 11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
01 Mathematical Sciences > 0104 Statistics > 010401 Applied Statistics
01 Mathematical Sciences > 0104 Statistics > 010402 Biostatistics
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970101 Expanding Knowledge in the Mathematical Sciences
Identification Number or DOI: 10.1007/s11695-016-2469-5
URI: http://eprints.usq.edu.au/id/eprint/30447

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