Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors

Dunn, Adam G. and Zhou, Xujuan and Hudgins, Joel and Arachi, Diana and Mandl, Kenneth D. and Coiera, Enrico and Bourgeois, Florence T. (2016) Financial competing interests were associated with favorable conclusions and greater author productivity in nonsystematic reviews of neuraminidase inhibitors. Journal of Clinical Epidemiology, 80. pp. 43-49. ISSN 0895-4356

Abstract

Objective:
To characterize the conclusions and production of nonsystematic reviews about neuraminidase inhibitors relative to financial competing interests held by the authors.

Study Design and Setting:
We searched for articles about neuraminidase inhibitors and influenza (January 2005 to April 2015), identifying nonsystematic reviews and grading them according to the favorable/nonfavorable presentation of evidence on safety and efficacy. We recorded financial competing interests disclosed in the reviews and from other articles written by their authors. We measured associations between competing interests, author productivity, and conclusions.

Results:
Among 213 nonsystematic reviews, 138 (65%) presented favorable conclusions. Financial competing interests were identified for 26% (137/532) of authors; 51% (108/213) of reviews were associated with a financial competing interest. Reviews produced exclusively by authors with financial competing interests (33%; 71/213) were more likely to present favorable conclusions than reviews with no competing interests (risk ratio 1.27; 95% confidence interval 1.03-1.55). Authors with financial competing interests published more articles about neuraminidase inhibitors than their counterparts.

Conclusion:
Half of nonsystematic reviews about neuraminidase inhibitors included an author with a financial competing interest. Reviews produced exclusively by these authors were more likely to present favorable conclusions, and authors with financial competing interests published a greater number of reviews.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to ArticleFirst version in accordance with the copyright policy of the publisher.
Faculty / Department / School: Current - Faculty of Business, Education, Law and Arts - School of Management and Enterprise
Date Deposited: 13 Jan 2017 01:58
Last Modified: 24 Jan 2018 01:59
Uncontrolled Keywords: Oseltamivir; Zanamivir; neuraminidase inhibitors; bibliometrics; competing interests; review literature as topic
Fields of Research : 11 Medical and Health Sciences > 1117 Public Health and Health Services > 111706 Epidemiology
Identification Number or DOI: 10.1016/j.jclinepi.2016.07.010
URI: http://eprints.usq.edu.au/id/eprint/29640

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