Loss of function of the IAA-glucose hydrolase gene TGW6 enhances rice grain weight and increases yield

Ishimaru, Ken and Hirotsu, Naoki and Madoka, Yuka and Murakami, Naomi and Hara, Nao and Onodera, Haruko and Kashiwagi, Takayuki and Ujiie, Kazuhiro and Shimizu, Bun-ichi and Onishi, Atsuko and Miyagawa, Hisashi and Katoh, Etsuko (2013) Loss of function of the IAA-glucose hydrolase gene TGW6 enhances rice grain weight and increases yield. Nature Genetics, 45 (6). pp. 707-711. ISSN 1061-4036


Increases in the yield of rice, a staple crop for more than half of the global population, are imperative to support rapid population growth. Grain weight is a major determining factor of yield. Here, we report the cloning and functional analysis of THOUSAND-GRAIN WEIGHT 6 (TGW6), a gene from the Indian landrace rice Kasalath. TGW6 encodes a novel protein with indole-3-acetic acid (IAA)-glucose hydrolase activity. In sink organs, the Nipponbare tgw6 allele affects the timing of the transition from the syncytial to the cellular phase by controlling IAA supply and limiting cell number and grain length. Most notably, loss of function of the Kasalath allele enhances grain weight through pleiotropic effects on source organs and leads to significant yield increases. Our findings suggest that TGW6 may be useful for further improvements in yield characteristics in most cultivars.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Files associated with this item cannot be displayed due to copyright restrictions.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 03 Aug 2016 05:08
Last Modified: 27 Sep 2019 04:55
Uncontrolled Keywords: plant breeding
Fields of Research (2008): 06 Biological Sciences > 0604 Genetics > 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
06 Biological Sciences > 0607 Plant Biology > 060702 Plant Cell and Molecular Biology
Fields of Research (2020): 31 BIOLOGICAL SCIENCES > 3105 Genetics > 310506 Gene mapping
31 BIOLOGICAL SCIENCES > 3108 Plant biology > 310803 Plant cell and molecular biology
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Identification Number or DOI: https://doi.org/10.1038/ng.2612
URI: http://eprints.usq.edu.au/id/eprint/28863

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