In vitro anti-Leishmanial effects of black tea extract components

Mahdi, H. S. and Al-Bashir, N. M and Saour, K. Y. and Mahdi, L. Kh. (2005) In vitro anti-Leishmanial effects of black tea extract components. Jordan Journal of Applied Science, 7 (2). pp. 38-50. ISSN 1605-2587

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Four components of black tea extract (tannic acid, caffeine, theophylline and theobromine) exhibited antileishmanial activity against L. donovani, L. tropica and L. major, in both promastigote and axenic amastigote stages. All components showed antileishmanial activity against the three species. The concentration used ranged between (0.623-3) mg/ml. It was found that tannic acid had the greater effect on Leishmania species than other components, with ED50 range between (0.025-0.05) mg/ml after three days of exposure. Caffeine and theophylline showed a potent activity against the three species of Leishmania, with ED50 range between (0.035-1) mg/ml and (0.5-1) mg/ml respectively. In contrast the ED50 for theobromine ranged between (0.72-3) mg\ml. These results suggest further assessment of the four components of tea extract in infected laboratory animals and in humans against Leishmania infections.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 27 Feb 2018 23:51
Last Modified: 27 Feb 2018 23:51
Uncontrolled Keywords: Black tea; Leishmania
Fields of Research : 06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060101 Analytical Biochemistry
11 Medical and Health Sciences > 1108 Medical Microbiology > 110803 Medical Parasitology
06 Biological Sciences > 0605 Microbiology > 060599 Microbiology not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences

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