Evidence based decision and meta-analysis with applications in cancer research studies

Khan, Shahjahan and Doi, Suhail A. R. and Memon, M. Ashraf (2016) Evidence based decision and meta-analysis with applications in cancer research studies. Applied Mathematics and Information Sciences, 10 (3). pp. 1-8. ISSN 1935-0090

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Abstract

In the age of evidence based decision making through systematic review of literature, the statistical meta-analysis has been extensively used to synthesise published summary data on a particular topic of interest from a number of independent studies in order to make credible and scientifically valid conclusions. The main objective is to estimate the common effect size as a pooled statistic
for any selected outcome variables through merging the relevant data. There are several issues concerning the quality and type of the published summary statistics and inherent heterogeneity among the estimates of the effect size across the studies. This paper covers several estimators of the common effect size and some of their major impacts in the meta-analysis and redistribution of weights to the individual studies. Some examples from recent literature on cancer research studies are used to illustrate the alternative estimators and discuss their usefulness in analysing data from randomised control trials in medical studies.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2016 NSP. Natural Sciences Publishing.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Agricultural, Computational and Environmental Sciences
Date Deposited: 23 Feb 2016 05:17
Last Modified: 03 May 2017 00:27
Uncontrolled Keywords: evidence based decision, systematic review, meta-analysis, heterogeneity, randomised control trial
Fields of Research : 01 Mathematical Sciences > 0104 Statistics > 010405 Statistical Theory
11 Medical and Health Sciences > 1117 Public Health and Health Services > 111706 Epidemiology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970101 Expanding Knowledge in the Mathematical Sciences
Identification Number or DOI: doi:10.12785/amis/paper-SK_print
URI: http://eprints.usq.edu.au/id/eprint/28419

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