Cyanidin 3-glucoside in diet-induced metabolic syndrome in rats

du Preez, Ryan (2015) Cyanidin 3-glucoside in diet-induced metabolic syndrome in rats. Honours thesis, University of Southern Queensland. (Unpublished)

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Abstract

Metabolic syndrome combines the risk factors for type 2 diabetes and cardiovascular disease, including obesity, insulin resistance, impaired glucose tolerance, dyslipidaemia and hypertension. Obesity is now understood to be a chronic low-grade inflammatory state with sustained oxidative stress. There are few drug therapies for obesity and all may produce unacceptable adverse effects. Thus, functional foods may serve as a better alternative for treatment of metabolic syndrome. Anthocyanins are purple-coloured polyphenolic compounds found in dark-coloured fruits and vegetables, such as purple carrot, Queen Garnet plum, chokeberry and purple corn. As anthocyanins produce anti-oxidant and anti-inflammatory responses, this study investigated whether anthocyanin-rich black rice can reverse the signs of diet-induced metabolic syndrome. This study used high-carbohydrate, high-fat diet-fed male Wistar rats to mimic the symptoms of human metabolic syndrome. Rats developed hypertension, diabetes along with damage to cardiovascular and hepatic systems. However, rats supplemented with cyanidin 3-glucoside rich black rice extract mid-way through the protocol had noticeable overall health improvements. Black rice extract reversed many changes the rats developed while on the diet including reduced body weight (10%), abdominal obesity (6%) and normalising systolic blood pressure; improved hepatic structure (decreased inflammation) and function; (decreased liver enzyme activity) improved cardiovascular structure (decreased inflammation and fibrosis) and function along with reduced overall cholesterol and decreased liver enzyme activity.


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Item Type: Thesis (Non-Research) (Honours)
Item Status: Live Archive
Additional Information: Bachelor of Science (Honours) thesis.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Supervisors: Panchal, Sunil; Brown, Lindsay
Date Deposited: 22 Dec 2015 01:40
Last Modified: 22 Dec 2015 01:45
Uncontrolled Keywords: diet-induced metabolic syndrome, anthocyanin, cyanidin 3-glucoside, obesity, Queen Garnet plum, purple carrots
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
URI: http://eprints.usq.edu.au/id/eprint/28263

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