Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

Iyer, Abishek and Brown, Lindsay and Whitehead, Jonathan P. and Prins, Johannes B. and Fairlie, David P. (2015) Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease. The FASEB Journal, 29 (9). pp. 3612-25. ISSN 0892-6638

Abstract

The growth and survival of multicellular organisms depend upon their abilities to acquire and metabolize nutrients, efficiently store and harness energy, and sense and fight infection. Systems for sensing and using nutrients have consequently coevolved alongside systems for sensing and responding to danger signals, including pathogens, and share many of the same cell signaling proteins and networks. Diets rich in carbohydrates and fats can overload these systems, leading to obesity, metabolic dysfunction, impaired immunity, and cardiovascular disease. Excessive nutrient intake promotes adiposity, typically altering adipocyte function and immune cell distribution, both of which trigger metabolic dysfunction. Here, we discuss novel mechanistic links between metabolism and immunity that underlie metabolic dysfunction in obesity. We aim to stimulate debate about how the endocrine and immune systems are connected through autocrine, paracrine, and neuroendocrine signaling in sophisticated networks that are only now beginning to be resolved. Understanding the expression and action of signaling proteins, together with modulating their receptors or pattern recognition using agonists or antagonists, will enable rational intervention in immunometabolism that may lead to novel treatments for obesity and metabolic dysfunction.-Iyer, A., Brown, L., Whitehead, J. P., Prins, J. B., Fairlie, D. P. Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease.

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Item Type:	Article (Commonwealth Reporting Category C)
Refereed:	Yes
Item Status:	Live Archive
Additional Information:	Published version restricted in accordance with the copyright policy of the publisher.
Faculty/School / Institute/Centre:	Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 -)
Faculty/School / Institute/Centre:	Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 -)
Date Deposited:	06 Jan 2016 02:17
Last Modified:	26 Apr 2016 03:04
Uncontrolled Keywords:	macrophage; toll-like receptors; inflammation; obesity; diabetes
Fields of Research (2008):	11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objectives (2008):	E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI:	https://doi.org/10.1096/fj.15-271155
URI:	http://eprints.usq.edu.au/id/eprint/27688

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