Panchal, Sunil K. and Poudyal, Hemant and Ward, Leigh C. and Waanders, Jennifer and Brown, Lindsay (2015) Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats. Food and Function, 6 (8). pp. 2496-2506. ISSN 2042-6496
This is the latest version of this item.
Abstract
Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. l-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8-9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with l-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. l-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, l-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential [small beta]-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues.
![]() |
Statistics for this ePrint Item |
Item Type: | Article (Commonwealth Reporting Category C) |
---|---|
Refereed: | Yes |
Item Status: | Live Archive |
Additional Information: | Permanent restricted access to Published version due to publisher's copyright policy. |
Faculty/School / Institute/Centre: | Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021) |
Faculty/School / Institute/Centre: | Historic - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing (1 Jan 2015 - 31 Dec 2021) |
Date Deposited: | 06 Jan 2016 02:07 |
Last Modified: | 22 Jul 2016 05:58 |
Uncontrolled Keywords: | metabolism, fatty acids, l-carnitine, obesity, cardiovascular remodelling |
Fields of Research (2008): | 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology |
Fields of Research (2020): | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology |
Socio-Economic Objectives (2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences |
Identification Number or DOI: | https://doi.org/10.1039/C5FO00480B |
URI: | http://eprints.usq.edu.au/id/eprint/27584 |
Available Versions of this Item
- Modulation of tissue fatty acids by l-carnitine attenuates metabolic syndrome in diet-induced obese rats. (deposited 06 Jan 2016 02:07) [Currently Displayed]
Actions (login required)
![]() |
Archive Repository Staff Only |