Should the pharmacological actions of dietary fatty acids in cardio-metabolic disorders be classified based on biological or chemical function?

Poudyal, Hemant and Brown, Lindsay (2015) Should the pharmacological actions of dietary fatty acids in cardio-metabolic disorders be classified based on biological or chemical function? Progress in Lipid Research, 59. pp. 172-200. ISSN 0163-7827

Abstract

Westernised dietary patterns are characterised by an increased intake of saturated (SFA) and trans fat (TFA) and a high n-6:n-3 polyunsaturated fatty acid (PUFA) ratio. These changes together with increased sugar intake have been implicated in the progression and development of metabolic syndrome. It is now recognised that the type of dietary fat plays a far more significant role in well-being than the absolute amount. This has led to the generalisations that TFA and SFA are detrimental, MUFA are neutral and PUFA are cardioprotective. However, different dietary fatty acids even within the same chemical class elicit different physiological responses. Thus, generalising fatty acids by the degree of unsaturation or the configuration of double bonds alone is unlikely to predict biological responses. In this review, we have examined the effects of different dietary fatty acids on the cardiometabolic risk factors and propose a revised classification based on current evidence of biological activity, rather than chemical structure. Specifically, we propose that dietary fatty acids be classified into five classes with neutral, reduce one or more cardiometabolic risk factors, increase one or more cardiometabolic risk factor, controversial evidence to allow classification and inadequate research to allow classification as a basis for further discussions.


Statistics for USQ ePrint 27583
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version due to publisher copyright policy.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 04 Jan 2016 23:44
Last Modified: 24 Jan 2018 00:58
Uncontrolled Keywords: cardiovascular, MUFA, PUFA, saturated fat, trans-fat
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.plipres.2015.07.002
URI: http://eprints.usq.edu.au/id/eprint/27583

Actions (login required)

View Item Archive Repository Staff Only