Cross-species comparison of CpG density in the promoter regions of protein kinase oncogenes

Pioth, Gabriel G. and Zhao, Kong-Nan and Liu, Guang B. (2015) Cross-species comparison of CpG density in the promoter regions of protein kinase oncogenes. Bioengineering and Bioscience, 3 (3). pp. 29-38. ISSN 2332-001X

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Abstract

In this report, we investigated CpG density occurred in promoter regions (PRs) and downstream flanking regions (DFR) of 61 human protein kinase oncogenes (PKOs), together with other three species: chimpanzee, mouse and horse. The quantified numbers of CpGs in the PRs of human PKOs were much higher than those of chimpanzee, mouse and horse, suggesting that the CpG density changes among the four species are associated with species evolution. Human PKOs with relatively high number of CpGs in the PRs showed stronger gene expression than the mouse PKOs in tumour tissues, but not in normal tissues. Furthermore, human PKOs with extremely high density of CpGs in the PRs exhibited much lower expression in tumour tissues than in normal tissues. Our data initially suggest that the occurrence and density of CpGs in the PRs of PKOs play an important role in regulating gene expression associated with the tumorigenesis. Thus, further improvement of our understanding of the density and spatial arrangement of CpGs in the PRs of PKOs and other oncogenes involved in tumorigenesis is very important for providing preventive and therapeutic strategies for human cancer.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Access to published version in accordance with the copyright policy of the publisher.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 14 Apr 2016 07:27
Last Modified: 04 Apr 2017 23:16
Uncontrolled Keywords: CpG Island , Protein Kinase Oncogene , Oncogenesis , Promoter Region, Transcription Start Sites
Fields of Research : 11 Medical and Health Sciences > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics
06 Biological Sciences > 0604 Genetics > 060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: doi:10.13189/bb.2015.030301
URI: http://eprints.usq.edu.au/id/eprint/27434

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