Wei, Michael and Ong, Leslie and Smith, Maree and Ross, Fraser B. and Schmid, Katrina and Hoey, Andrew and Burstow, Darryl and Brown, Lindsay (2003) The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart, Lung and Circulation, 12 (1). pp. 44-50. ISSN 1443-9506
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Abstract
Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin(STZ)-induced diabetes in the rat.
Methods: This project has assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post-STZ treatment in rats.
Results: STZ-diabetic rats (n=96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in body weight); 52% of untreated STZ-diabetic rats (n=50) survived 24 weeks. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks.
Conclusion: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.
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Item Type: | Article (Commonwealth Reporting Category C) |
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Refereed: | Yes |
Item Status: | Live Archive |
Additional Information: | Deposited in accordance with the copyright policy of the publisher. |
Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013) |
Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013) |
Date Deposited: | 11 Oct 2007 01:13 |
Last Modified: | 15 Aug 2017 02:34 |
Uncontrolled Keywords: | diabetes; echocardiography; electrophysiology; neuropathic pain; cataracts; retinopathy |
Fields of Research (2008): | 06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified |
Identification Number or DOI: | https://doi.org/10.1046/j.1444-2892.2003.00160.x |
URI: | http://eprints.usq.edu.au/id/eprint/2736 |
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