Wei, Michael and Ong, Leslie and Smith, Maree and Ross, Fraser B. and Schmid, Katrina and Hoey, Andrew and Burstow, Darryl and Brown, Lindsay (2003) The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart, Lung & Circulation, 12 (1). pp. 44-50. ISSN 1444-2892
Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin(STZ)-induced diabetes in the rat.
Methods: This project has assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post-STZ treatment in rats.
Results: STZ-diabetic rats (n=96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in body weight); 52% of untreated STZ-diabetic rats (n=50) survived 24 weeks. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks.
Conclusion: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.
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|Item Type:||Article (Commonwealth Reporting Category C)|
|Item Status:||Live Archive|
|Additional Information:||Deposited in accordance with the copyright policy of the publisher.|
|Faculty / Department / School:||Historic - Faculty of Sciences - Department of Biological and Physical Sciences|
|Date Deposited:||11 Oct 2007 01:13|
|Last Modified:||02 Jul 2013 22:46|
|Uncontrolled Keywords:||diabetes; echocardiography; electrophysiology; neuropathic pain; cataracts; retinopathy|
|Fields of Research :||06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified|
|Identification Number or DOI:||doi: 10.1046/j.1444-2892.2003.00160.x|
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