Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients

Liu, Guang Bin and Chen, Jiezhong and Wu, Zhan He and Zhao, Kong-Nan (2015) Association of human papillomavirus with Fanconi anemia promotes carcinogenesis in Fanconi anemia patients. Reviews in Medical Virology, 25 (6). pp. 345-353. ISSN 1052-9276

Abstract

Fanconi anemia (FA) is a rare recessive disorder associated with chromosomal fragility. FA patients are at very high risk of cancers, especially head and neck squamous cell carcinomas and squamous cell carcinomas caused by infection of human papillomaviruses (HPVs). By integrating into the host genome, HPV oncogenes E6 and E7 drive the genomic
instability to promote DNA damage and gene mutations necessary for carcinogenesis in FA patients. Furthermore,
E6 and E7 oncoproteins not only inhibit p53 and retinoblastoma but also impair the FANC/BRCA signaling pathway to prevent DNA damage repair and alter multiple signals including cell-cycle checkpoints, telomere function, cell proliferation, and interference of the host immune system leading to cancer development in FA patients. In this review, we summarize recent advances in unraveling the molecular mechanisms of FA susceptibility to HPV-induced cancers, which facilitate rational preventive and therapeutic strategies.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version due to publisher copyright policy.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Health and Wellbeing
Date Deposited: 10 Apr 2015 01:52
Last Modified: 16 Sep 2016 07:03
Uncontrolled Keywords: Fanconi anemia; head and neck cancers; human papillomaviruses
Fields of Research : 06 Biological Sciences > 0605 Microbiology > 060506 Virology
06 Biological Sciences > 0604 Genetics > 060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)
11 Medical and Health Sciences > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: 10.1002/rmv.1834
URI: http://eprints.usq.edu.au/id/eprint/26913

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