Induction of metabolic syndrome by excess fructose consumption

Wong, Weng-Yew and Brown, Lindsay (2014) Induction of metabolic syndrome by excess fructose consumption. In: Diabetic cardiomyopathy: biochemical and molecular mechanisms. Advances in Biochemistry in Health and Disease, 9. Springer, New York, NY. United States, pp. 41-63. ISBN 978-1-4614-9316-7


Fructose is an important nutritive component of foods such as honey and fruit, but this easily available sweetener may contribute to increased caloric consumption from overeating. Fructose is now a major component of the Western diet, with increased consumption associated with obesity, metabolic syndrome, and cardiovascular disorders in observational and short-term intervention studies,
mainly in animal models. Rodent studies have identified possible mechanisms for the adverse effects of fructose when ingested in large amounts. Fructose promoted de novo lipogenesis, inflammation, and increased sympathetic tone. These mechanisms induced hepatic insulin resistance, increased total and visceral fat mass with accumulation of ectopic fat in the liver and skeletal muscle, and dyslipidemia. Fructose reduced leptin and insulin signals for satiety, caused structural and functional damage to the heart and blood vessels, and disrupted the diversity of the gut microbiota. These early effects may initiate the development of the metabolic syndrome. Despite this evidence from rodents, there are few long-term intervention studies in humans, especially at a moderate dose. The definition of prudent fructose consumption is needed, but this will require carefully controlled dose–response studies in humans.

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Item Type: Book Chapter (Commonwealth Reporting Category B)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher copyright policy.
Faculty/School / Institute/Centre: Historic - Faculty of Health, Engineering and Sciences - School of Health, Nursing and Midwifery
Date Deposited: 06 May 2015 05:50
Last Modified: 05 Dec 2017 01:16
Uncontrolled Keywords: fructose; metabolic syndrome; leptin; insulin; lipogenesis; hypertension; inflammation; gut microbiota; cardiac hypertrophy
Fields of Research : 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1007/978-1-4614-9317-4_3

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