Obesity and metabolic syndrome

Panchal, Sunil K. and Bhaswant, Maharshu and Brown, Lindsay (2014) Obesity and metabolic syndrome. In: In vivo models for drug discovery. Methods and principles in medicinal chemistry, 62. John Wiley & Sons Ltd., Weinheim, Germany, pp. 333-348. ISBN 978-3-527-33328-8


Obesity has reached epidemic proportions throughout the world, leading to increased cardiovascular disease and diabetes. Defining new treatment options requires initial studies on animal models that mimic the range of long-term health problems in chronically obese humans, before studies are undertaken on these obese humans. This chapter reviews genetic and diet-induced models of obesity and the metabolic syndrome in rats. Translation of rat results into humans requires more studies.

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Item Type: Book Chapter (Commonwealth Reporting Category B)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2014 Wiley. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - No Department
Date Deposited: 27 Feb 2015 06:19
Last Modified: 16 Aug 2017 03:36
Uncontrolled Keywords: animal models; rat models; diabetes; dyslipidemia; genetic models; metabolic syndrome; obesity
Fields of Research : 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Objective: C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition
Identification Number or DOI: 10.1002/9783527679348.ch15
URI: http://eprints.usq.edu.au/id/eprint/26812

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