Panchal, Sunil K. and Bhaswant, Maharshu and Brown, Lindsay (2014) Obesity and metabolic syndrome. In: In vivo models for drug discovery. Methods and principles in medicinal chemistry, 62. John Wiley & Sons Ltd., Weinheim, Germany, pp. 333-348. ISBN 978-3-527-33328-8
Abstract
Obesity has reached epidemic proportions throughout the world, leading to increased cardiovascular disease and diabetes. Defining new treatment options requires initial studies on animal models that mimic the range of long-term health problems in chronically obese humans, before studies are undertaken on these obese humans. This chapter reviews genetic and diet-induced models of obesity and the metabolic syndrome in rats. Translation of rat results into humans requires more studies.
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