Review: finding the culprit: a review of the influences of proteases on the chronic wound environment

Rayment, Erin A. and Upton, Zee (2009) Review: finding the culprit: a review of the influences of proteases on the chronic wound environment. International Journal of Lower Extremity Wounds, 8 (1). pp. 19-27. ISSN 1534-7346


Chronic leg ulcers are a complex medical condition with varied underlying causes and requiring diverse treatment strategies. It is generally accepted that chronic ulcers occur when the normal wound healing process is interrupted. These wounds are characterized by excessive protease activity, abundant granulation tissue, and decreased levels of growth factors, resulting in an overall poor prognosis for the patient. Many studies have focused on identifying the key proteases, specifically matrix metalloproteinases (MMPs), responsible for an ulcer's chronicity. Of note, the results of these studies are often conflicting. This report therefore focuses on a review of this literature to identify which MMPs are important in terms of ulcer prognosis and healing outcome. This has revealed that MMPs are clearly important in many biological processes in wound healing, hence are critical to consider when developing improved therapies to enhance both ulcer healing times and ulcer healing outcomes.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2009 SAGE Publications. Permanent restricted access to published version due to publisher copyright policy.
Faculty/School / Institute/Centre: No Faculty
Faculty/School / Institute/Centre: No Faculty
Date Deposited: 06 Nov 2014 00:03
Last Modified: 07 Nov 2014 04:25
Uncontrolled Keywords: chronic leg ulcer; matrix metalloproteinase; wound healing
Fields of Research (2008): 11 Medical and Health Sciences > 1116 Medical Physiology > 111603 Systems Physiology
10 Technology > 1004 Medical Biotechnology > 100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
11 Medical and Health Sciences > 1108 Medical Microbiology > 110801 Medical Bacteriology
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3208 Medical physiology > 320803 Systems physiology
32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320606 Regenerative medicine (incl. stem cells)
32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology
Socio-Economic Objectives (2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases
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