Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds

Upton, Zee and Wallace, Hilary J. and Shooter, Gary K. and van Lonkhuyzen, Derek R. and Yeoh-Ellerton, Sim and Rayment, Erin A. and Fleming, Jacqui M. and Broszczak, Daniel and Queen, Douglas and Sibbald, R. Gary and Leavesley, David I. and Stacey, Michael C. (2011) Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds. International Wound Journal, 8 (5). pp. 522-532. ISSN 1742-4801

Abstract

Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high costs have limited their widespread adoption. Many treatments have ignored the evidence that wound healing is driven by interactions between extracellular matrix proteins and GFs, not just GFs alone. We report herein that a clinical Good Manufacturing Practice-grade vitronectin:growth factor (cVN:GF) complex is able to stimulate functions relevant to wound repair in vitro, such as enhanced cellular proliferation and migration. Furthermore, we assessed this complex as a topical wound healing agent in a single-arm pilot study using venous leg ulcers, as well as several 'difficult to heal' case studies. The cVN:GF complex was safe and re-epithelialisation was observed in all but 1 of the 30 patients in the pilot study. In addition, the case studies show that this complex may be applied to several ulcer aetiologies, such as venous leg ulcers, diabetic foot ulcers and pressure ulcers. These findings suggest that further evaluation is warranted to determine whether the cVN:GF complex may be an effective topical treatment for chronic wounds.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2011 The Authors. © 2011 Blackwell Publishing Ltd. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: No Faculty
Date Deposited: 05 Nov 2014 05:22
Last Modified: 31 Jan 2017 01:58
Uncontrolled Keywords: chronic wound; growth factors; topical treatment; wound healing; Vitronectin
Fields of Research : 06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060103 Cell Development, Proliferation and Death
11 Medical and Health Sciences > 1108 Medical Microbiology > 110802 Medical Infection Agents (incl. Prions)
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: 10.1111/j.1742-481X.2011.00859.x
URI: http://eprints.usq.edu.au/id/eprint/26324

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