Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

Beattie, Karren D. and Thompson, Dion R. and Tiralongo, Evelin and Ratkowsky, David and May, Tom W. and Gill, Melvyn (2011) Austrocolorone B and Austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini. Tetrahedron Letters, 52 (42). pp. 5448-5451. ISSN 0040-4039

Abstract

The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinarius vinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10–31 lg/mL.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2011 Elsevier Ltd. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Nursing
Date Deposited: 17 Aug 2014 05:36
Last Modified: 09 Feb 2017 05:16
Uncontrolled Keywords: Cytotoxic; Anthraquinone; Tricolorin; Australian fungi
Fields of Research : 03 Chemical Sciences > 0306 Physical Chemistry (incl. Structural) > 030606 Structural Chemistry and Spectroscopy
03 Chemical Sciences > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
03 Chemical Sciences > 0305 Organic Chemistry > 030502 Natural Products Chemistry
11 Medical and Health Sciences > 1112 Oncology and Carcinogenesis > 111205 Chemotherapy
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders
Funding Details:
Identification Number or DOI: 10.1016/j.tetlet.2011.08.015
URI: http://eprints.usq.edu.au/id/eprint/25711

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