Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro

Beattie, Karren D. and Ulrich, Rahel and Grice, I. Darren and Uddin, Shaikh and Blake, Tony B. and Wood, Kyle A. and Steele, Jules and Iu, Fontaine and May, Tom W. and Tiralongo, Evelin (2011) Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro. Mycologia, 103 (3). pp. 458-465. ISSN 0027-5514

Abstract

Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published Version restricted in accordance with publisher copyright policy
Faculty / Department / School: Historic - Faculty of Sciences - No Department
Date Deposited: 13 Aug 2014 22:11
Last Modified: 09 Feb 2017 05:16
Uncontrolled Keywords: bioactivity, Coprinus, Cordyceps, cytotoxic,drug discovery, Hypholoma, Lepista, Leratiomyces,macrofungi, Omphalotus, Ophiocordyceps
Fields of Research : 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
06 Biological Sciences > 0605 Microbiology > 060505 Mycology
03 Chemical Sciences > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl.Clinical Toxicology)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders
Identification Number or DOI: 10.3852/10-121
URI: http://eprints.usq.edu.au/id/eprint/25708

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