Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae)

Beattie, Karren D. and Waterman, Peter G. and Forster, Paul I. and Thompson, Dion R. and Leach, David N. (2011) Chemical composition and cytotoxicity of oils and eremophilanes derived from various parts of Eremophila mitchellii Benth (Myoporaceae). Phytochemistry, 72 (4-5). pp. 400-408. ISSN 0031-9422


A detailed investigation of the wood, leaf, branch and root oil of Eremophila mitchellii (Benth.) was carried out by a combination of GC–FID, GC–MS and NMR. The wood oil was composed predominantly of eremophilanes, a rare class of biologically active, bicyclic sesquiterpenoids. The root oil was also found to contain the eremophilanes together with the zizaene sesquiterpene, sesquithuriferone. 9-Hydroxy-1,7(11),9-eremophilatrien-8-one and the known 1(10),11-eremophiladien-9-one (eremophilone), 9-hydroxy-7(11),9-eremophiladien-8-one (2-hydroxyeremophilone), 8-hydroxy-11-eremophilen-9-one (santalcamphor), 8-hydroxy-10,11-eremophiladien-9-one, sesquithuriferone and 8-hydroxy-1,11-eremophiladien-9-one were purified and elucidated by NMR. Three approaches to the purification of the major eremophilanes from the wood oil are described. (+) Spathulenol, α-pinene, globulol, viridiflorene were the major constituents of the leaf oil. All of the essential oils and the eremophilanes exhibited cytotoxicity against P388D1 mouse lymphoblast cells in-vitro.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2011 Elsevier Ltd. Restricted access in accordance with the publisher copyright policy.
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Nursing
Date Deposited: 17 Aug 2014 06:31
Last Modified: 06 Mar 2018 04:53
Uncontrolled Keywords: Eremophila mitchellii; Myoporaceae; Cytotoxic; Sesquiterpene; Eremophilane; essential oil; Eremophilone; Santalcamphor; wood oil
Fields of Research : 03 Chemical Sciences > 0306 Physical Chemistry (incl. Structural) > 030606 Structural Chemistry and Spectroscopy
03 Chemical Sciences > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
03 Chemical Sciences > 0305 Organic Chemistry > 030502 Natural Products Chemistry
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Identification Number or DOI: 10.1016/j.phytochem.2010.12.011

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