Antibacterial metabolites from Australian macrofungi from the genus Cortinarius

Beattie, Karren D. and Rouf, Razina and Gander, Louisa and May, Tom W. and Ratkowsky, David and Donner, Christopher D. and Gill, Melvyn and Grice, I. Darren and Tiralongo, Evelin (2010) Antibacterial metabolites from Australian macrofungi from the genus Cortinarius. Phytochemistry, 71 (8-9). pp. 948-955. ISSN 0031-9422

Abstract

In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybecanaria] 2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of ⩽0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 ⩽ 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7–12 μg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 μg/mL, respectively).


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2010 Elsevier Ltd. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Nursing
Date Deposited: 18 Aug 2014 12:25
Last Modified: 09 Mar 2015 22:41
Uncontrolled Keywords: Cortinarius basirubescens; Cortinarius; Dermocybe; Australian fungi; antimicrobial; antibacterial; Staphylococcus aureus; Pseudomonas aeruginosa; pigments; Anthraquinones
Fields of Research : 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
03 Chemical Sciences > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules
03 Chemical Sciences > 0305 Organic Chemistry > 030502 Natural Products Chemistry
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases
Identification Number or DOI: 10.1016/j.phytochem.2010.03.016
URI: http://eprints.usq.edu.au/id/eprint/25697

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