Estrogen-induced cholestasis: pathogenesis and therapeutic implications

Chen, Jiezhong and Zhao, Kong-Nan and Liu, Guang Bin (2013) Estrogen-induced cholestasis: pathogenesis and therapeutic implications. Hepato-gastroenterology, 60 (126). pp. 1296-1299. ISSN 0172-6390

Abstract

Cholestasis syndromes characterised by impairment of bile formation and secretion are caused by many diseases. Estrogen-induced cholestasis among the cholestasis syndromes is a very common form. Based on the molecular studies of bile formation and transportation, a significant advancement has been achieved in understanding the mechanism of the disease. Estrogen can inhibit bile acids transportation from hepatocytes into bile canaliculi by interfering with the bile salt export pump and multidrug resistance-associated transporter 2 as well. It also inhibits Na+-taurocholate cotransporting polypeptide and Na+-independent organic anion-transporting polypeptides in the basolateral membrane of hepatocytes to interfere with the uptake of bile acids. Thus, co-treatment strategy can be considered which combines nuclear receptor inducers and cAMP enhancer to increase bile acids transporters activities, and the agents to reduce serum estrogen concentration and its receptor binding, and to reduce bile acids in enterohepatic circulation.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © H.G.E. Update Medical Publishing S.A., Athens. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Health, Engineering and Sciences - School of Health, Nursing and Midwifery
Date Deposited: 30 Oct 2013 23:24
Last Modified: 12 Nov 2014 01:49
Uncontrolled Keywords: estrogen; cholestasis; multidrug resistance-associated transporter; bile acids
Fields of Research : 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids
11 Medical and Health Sciences > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology
10 Technology > 1004 Medical Biotechnology > 100403 Medical Molecular Engineering of Nucleic Acids and Proteins
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.5754/hge121061
URI: http://eprints.usq.edu.au/id/eprint/24223

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