Surface coating of poly-D-L-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement

Chen, Ling and Tang, Chak Yin and Ku, Harry Siu Lung and Chen, Da Zhu and Tsui, Chi Pong (2013) Surface coating of poly-D-L-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement. In: Materials Science and Technology Conference (MS&T 2012): Next Generation Biomaterials and Surface Properties of Biomaterials , 27-31 Oct 2012, Pittsburgh, PA. United States.

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Abstract

Biodegradable polymeric nano-composite scaffolds have recently attracted considerable attention in curing bone deficiencies resulting from fractures or traumas. In this article, the latest progress in fabrication and characterization of poly-D-L-lactide/nano-hydroxyapatite (PDLLA/nano-HA) composite scaffolds, with poly (ethylene glycol) (PEG)-coating and dexamethasone (Dex)-releasing for bone tissue engineering is presented. For the design of drug release scaffolds, some aspects related to the choice of polymer matrix, bioactive inclusions, drug release coatings, and fabrication techniques are firstly reviewed. A PEG-based coating method was subsequently developed to modify a biodegradable polymeric nano-composite scaffold in providing a drug release function with improved wettability. The changes of water contact angle of the scaffolds before and after PEG/Dex coating were measured and the drug release function of the PEG/Dex coating was studied. The experimental findings showed that the proposed coating method was effective in enhancing the wettability and in controlling the early stage of drug release of the PDLLA/nano-HA composite scaffold.


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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)
Refereed: Yes
Item Status: Live Archive
Additional Information: Copyright © 2013 by The American Ceramic Society. All rights reserved. Series: Ceramic Transactions, vol. 242. Electronic copy held USQ Library. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, without the prior written permission of the Publisher.
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Mechanical and Electrical Engineering
Date Deposited: 14 Oct 2013 23:16
Last Modified: 15 Sep 2014 03:22
Uncontrolled Keywords: bone tissue engineering; coating methods; composite scaffolds; Dexamethasones; fabrication and characterizations; fabrication technique; surface coatings; water contact angle
Fields of Research : 10 Technology > 1007 Nanotechnology > 100703 Nanobiotechnology
09 Engineering > 0912 Materials Engineering > 091202 Composite and Hybrid Materials
09 Engineering > 0903 Biomedical Engineering > 090301 Biomaterials
Socio-Economic Objective: C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis)
Identification Number or DOI: 10.1002/9781118751015
URI: http://eprints.usq.edu.au/id/eprint/24138

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