Simulation study of pO2 distribution in induced tumour masses and normal tissues within a microcirculation environment

Li, Mao and Li, Yan and Wen, Peng (Paul) (2014) Simulation study of pO2 distribution in induced tumour masses and normal tissues within a microcirculation environment. Computer Methods in Biomechanics and Biomedical Engineering, 17 (4). pp. 334-343. ISSN 1025-5842

Abstract

The biological microenvironment is interrupted when tumour masses are introduced because of the strong competition for
oxygen. During the period of avascular growth of tumours, capillaries that existed play a crucial role in supplying oxygen to both tumourous and healthy cells. Due to limitations of oxygen supply from capillaries, healthy cells have to compete for oxygen with tumourous cells. In this study, an improved Krogh's cylinder model which is more realistic than the previously reported assumption that oxygen is homogeneously distributed in a microenvironment, is proposed to describe the process of the oxygen diffusion from a capillary to its surrounding environment. The capillary wall permeability is also taken into account. The simulation study is conducted and the results show that when tumour masses are implanted at the upstream part
of a capillary and followed by normal tissues, the whole normal tissues suffer from hypoxia. In contrast, when normal tissues are ahead of tumour masses, their pO2 is sufficient. In both situations, the pO2 in the whole normal tissues drops significantly due to the axial diffusion at the interface of normal tissues and tumourous cells. As the existence of the axial oxygen diffusion cannot supply the whole tumour masses, only these tumourous cells that are near the interface can be partially supplied, and have a small chance to survive.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2014 © 2012 Taylor & Francis. Published online 15 May 2012. Permanent restricted access to published version due to publisher copyright policy
Faculty / Department / School: Current - Faculty of Health, Engineering and Sciences - School of Agricultural, Computational and Environmental Sciences
Date Deposited: 19 Apr 2013 05:06
Last Modified: 11 May 2015 00:21
Uncontrolled Keywords: avascular growth; cylinder model; oxygen transport; tumours
Fields of Research : 11 Medical and Health Sciences > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology
06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060103 Cell Development, Proliferation and Death
08 Information and Computing Sciences > 0801 Artificial Intelligence and Image Processing > 080110 Simulation and Modelling
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970108 Expanding Knowledge in the Information and Computing Sciences
Identification Number or DOI: 10.1080/10255842.2012.683428
URI: http://eprints.usq.edu.au/id/eprint/23358

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