Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats

Alam, Md. Ashraful and Kauter, Kathleen and Withers, Kerry and Sernia, Conrad and Brown, Lindsay (2013) Chronic l-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats. Food and Function, 4 (1). pp. 83-91. ISSN 2042-6496


l-Arginine is an important dietary amino acid in both health and disease, especially of the cardiovascular system. This study has determined whether dietary supplementation with l-arginine attenuates cardiovascular, metabolic, pancreatic and liver changes in a rat model of the human metabolic syndrome. Male Wistar rats (8-9 weeks old) were divided into four groups. Two groups of rats were fed a corn starch-rich diet (C) whereas the other two groups were given a high carbohydrate, high fat diet (H) with 25% fructose in the drinking water, for 16 weeks. One group fed each diet was supplemented with 5% l-arginine in the food for the final 8 weeks of this protocol. The corn starch diet (C) contained ∼68% carbohydrates mainly as polysaccharides, while the high-carbohydrate, high-fat diet contained ∼68% carbohydrates mainly as fructose and sucrose together with 24% fat mainly as saturated and monounsaturated fats from beef tallow. The high-carbohydrate, high-fat diet-fed rats showed the symptoms of metabolic syndrome including obesity and hypertension with heart and liver damage. Supplementation with l-arginine attenuated impairment in left ventricular and liver structure and function, glucose tolerance, and decreased blood pressure, abdominal fat pads, inflammatory cell infiltration, pancreatic cell hypertrophy and oxidative stress. This study indicates that oral supplementation with l-arginine attenuated or normalised obesity-related changes in the heart, liver and pancreas by reducing inflammation and oxidative stress associated with high carbohydrate, high fat feeding in rats.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to Published version due to publisher's copyright policy.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 30 Jul 2013 02:41
Last Modified: 06 Jan 2016 02:06
Uncontrolled Keywords: corn starch; diet-induced obesity; dietary supplementation; four-group; glucose tolerance; high-fat diet; inflammatory cells; l-arginine; left ventricular; liver damage; metabolic syndromes; pancreatic cells; rat model; Wistar rat
Fields of Research : 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
06 Biological Sciences > 0608 Zoology > 060802 Animal Cell and Molecular Biology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1039/c2fo30096f

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