The role of n-3 polyunsaturated fatty acids in human heart failure

Poudyal, Hemant and Brown, Lindsay (2013) The role of n-3 polyunsaturated fatty acids in human heart failure. Endocrine, Metabolic and Immune Disorders - Drug Targets, 13 (1). pp. 105-117. ISSN 1871-5303


The n-3 polyunsaturated fatty acids (PUFA) have been proposed as potential treatments for human heart failure. The cardioprotective effects of n-3 PUFA are supported by extensive cell culture, animal and human studies. Animal studies with n-3 PUFA have shown marked improvements in many independent risk factors for heart failure, including obesity, type II diabetes, insulin resistance, hypertension and inflammation. However, the evidence from observational studies, randomised controlled trials and meta-analyses that these benefits on risk factors lead to improvements in the symptoms of heart failure in patients is much less convincing. Further, most studies have used marine n-3 PUFA; the role of the plant-derived PUFA, α-linolenic acid (ALA), is even less clear. This discontinuity of scientific evidence from animal to human studies suggests that future studies should focus on defining the optimal dosage range and the efficacy of n-3 PUFA compared to standard treatments using standardised study designs. Further studies on ALA would seem justified.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 17 Apr 2013 22:36
Last Modified: 06 Feb 2017 06:11
Uncontrolled Keywords: alpha-linolenic acid; docosahexaenoic acid; eicosapentaenoic acid; heart failure; omega-3 fatty acids
Fields of Research : 06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060104 Cell Metabolism
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.2174/1871530311313010013

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