Endurance exercise in a rat model of metabolic syndrome

Cameron, Isabelle and Alam, Mohammed Ashraful and Wang, Jianxiong and Brown, Lindsay (2012) Endurance exercise in a rat model of metabolic syndrome. Canadian Journal of Physiology and Pharmacology, 90 (11). pp. 1490-1497. ISSN 0008-4212


We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated into corn starch (CS) or HCHF diet groups for 16 weeks; half of each group were exercised on a treadmill for 20, 25, and then 30 min/day, 5 days/week, during the last 8 weeks of the protocol. Metabolic, cardiovascular, and liver parameters were monitored. The HCHF diet induced symptoms of metabolic syndrome, including obesity, dyslipidemia, impaired glucose tolerance, and increased systolic blood pressure associated with the development of cardiovascular remodeling and nonalcoholic steatohepatitis. Exercise in HCHF rats decreased body mass, abdominal fat pads and circumference, blood glucose concentrations, plasma lipid profiles, systolic blood pressure, left ventricular diastolic stiffness, collagen deposition and inflammatory cell infiltration in the left ventricle, improved aortic contractile and relaxation responses, and decreased liver mass and hepatic fat accumulation. This study demonstrates that endurance exercise is effective in this rat model of diet-induced metabolic syndrome in improving body composition and glucose regulation, as well as cardiovascular and liver structure and function.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher copyright policy.
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 13 Mar 2013 12:45
Last Modified: 18 Aug 2014 23:48
Uncontrolled Keywords: body composition, glucose tolerance, cardiac remodeling, endothelial dysfunction, liver function
Fields of Research : 11 Medical and Health Sciences > 1116 Medical Physiology > 111699 Medical Physiology not elsewhere classified
Identification Number or DOI: 10.1139/y2012-097
URI: http://eprints.usq.edu.au/id/eprint/22348

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